Table 1 Effect of low dose nitisinone on alkaptonuria-related variables
N patients | Duration | Dose | Δ uHGA (%) | Mean pTyrosine on treatment (µmol/l) | |
|---|---|---|---|---|---|
Suwannarat et al. [15] | 9 | 3–4 mo | 1.05 mg bid | − 94 | 755 ± 167 |
603 ± 114* | |||||
Introne et al. [8] | 40 | 4 mo–3 yrs | 2 mg od | − 95 | 670–826 |
Sloboda et al. [16] | 3 | 3–5 yrs | 0.2 mg od | − 90 | 305–416 |
Ranganath et al. [14] | 8 | 4 wks | 1 mg od | − 89.4 | 653 (450–806) |
8 | 2 mg od | − 94.9 | 715 (506–865) | ||
8 | 4 mg od | − 98.3 | 803 (657–1115) | ||
8 | 8 mg od | − 99 | 813 (523–927) |