| |
N patients
|
Duration
|
Dose
|
Δ uHGA (%)
|
Mean pTyrosine on treatment (µmol/l)
|
|---|
|
Suwannarat et al. [15]
|
9
|
3–4 mo
|
1.05 mg bid
|
− 94
|
755 ± 167
|
|
603 ± 114*
|
|
Introne et al. [8]
|
40
|
4 mo–3 yrs
|
2 mg od
|
− 95
|
670–826
|
|
Sloboda et al. [16]
|
3
|
3–5 yrs
|
0.2 mg od
|
− 90
|
305–416
|
|
Ranganath et al. [14]
|
8
|
4 wks
|
1 mg od
|
− 89.4
|
653 (450–806)
|
|
8
|
2 mg od
|
− 94.9
|
715 (506–865)
|
|
8
|
4 mg od
|
− 98.3
|
803 (657–1115)
|
|
8
|
8 mg od
|
− 99
|
813 (523–927)
|
- *After initiation of protein restriction
- Bid, twice daily; mo, months; N, number; od, once daily; uHGA, urinary homogentisic acid excretion
