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Table 2 Univariate analysis of risk factors for OS in newly diagnosed adult HLH patients

From: Increased levels of serum interleukin-10 are associated with poor outcome in adult hemophagocytic lymphohistiocytosis patients

Prognostic factor

Overall

HR

95%CI

P

Hemoglobin < 8.2 g/dL

1.853

1.069, 3.213

0.028*

Platelets < 40 × 109/L

1.798

1.072, 3.015

0.026*

Fibrinogen < 2.0 g/L

0.871

0.520, 1.458

0.599

LDH ≥ 700 IU/L

1.711

1.012, 2.891

0.045*

Albumin < 28 g/L

2.341

1.148, 4.775

0.019*

Triglycerides > 220 mg/dL

0.997

0.571, 1.741

0.993

Ferritin > 2000 µg/L

0.663

0.371, 1.184

0.165

Post-treatment ferritin > 1050 µg/L

4.964

2.760, 8.926

 < 0.001*

IL-1β ≥ 5 pg/mL

1.327

0.650, 2.705

0.437

IL-8 ≥ 32 pg/mL

1.312

0.780, 2.207

0.307

IL-10 ≥ 129 pg/mL

6.736

3.567, 12.721

 < 0.001*

  1. HR, hazard ratio; CI, confidence interval
  2. *Indicates statistically significant values
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172