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Table 2 Univariate analysis of risk factors for OS in newly diagnosed adult HLH patients

From: Increased levels of serum interleukin-10 are associated with poor outcome in adult hemophagocytic lymphohistiocytosis patients

Prognostic factor Overall
HR 95%CI P
Hemoglobin < 8.2 g/dL 1.853 1.069, 3.213 0.028*
Platelets < 40 × 109/L 1.798 1.072, 3.015 0.026*
Fibrinogen < 2.0 g/L 0.871 0.520, 1.458 0.599
LDH ≥ 700 IU/L 1.711 1.012, 2.891 0.045*
Albumin < 28 g/L 2.341 1.148, 4.775 0.019*
Triglycerides > 220 mg/dL 0.997 0.571, 1.741 0.993
Ferritin > 2000 µg/L 0.663 0.371, 1.184 0.165
Post-treatment ferritin > 1050 µg/L 4.964 2.760, 8.926  < 0.001*
IL-1β ≥ 5 pg/mL 1.327 0.650, 2.705 0.437
IL-8 ≥ 32 pg/mL 1.312 0.780, 2.207 0.307
IL-10 ≥ 129 pg/mL 6.736 3.567, 12.721  < 0.001*
  1. HR, hazard ratio; CI, confidence interval
  2. *Indicates statistically significant values