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Table 5 FISH, AB type, FCM and chromosomal karyotyping of BAL with KMT2Ar according to the literature review

From: Mature B cell acute lymphoblastic leukaemia with KMT2A-MLLT3 transcripts in children: three case reports and literature reviews

Pt

KMT2A-FISH

MYC-FISH

Transcripta

Protocol

Treatment response

HSCT

Relapse

EFS (m)

1

ND

ND

ND

VLP

Refractory

Refractory

Refractory

9 (OS)

2

Pos

ND

KMT2A + 

LMB89

CR

0

BM, CNS

9

3

Neg

Neg

ND

COG-ALL-1961

CR

No

No

9

4

Pos

Neg

ND

CCG-ALL-1991

CR

No

No

4

5

Pos

Neg

ND

Infant ALL

CR

No

No

4

6

Pos

Neg

ND

Interfant-99

CR

No

BM, TL

4

7

Pos

Neg

ND

Interfant-99

CR

4/6 matched CBT

BM

6

8

Pos

Neg

ND

LMB89 trial

CR

No

BM, CNS

6

9

ND

Neg

ND

EORTC 02

CR

No

BM, CNS

6

10

Pos

Neg

KMT2A-MLLT10

Interfant-99

CR

No

No

24

11

Pos

Neg

ND

FRALLE 2000

CR

No

No

35

12

Pos

Neg

ND

Interfant-99

CR

No

TL

14

13

Pos

ND

ND

ALL like

Died

died

died

1.25 (OS)

14

Pos

Neg

KMT2A-MLLT3

ALL

CR

No

No

8

15

Neg

Neg

Neg

ALL

CR

No

No

48

16

Pos

ND

KMT2A/MLLT5

Interfant-99

CR

No

BM, TL

4

17

Pos

ND

KMT2A-MLLT1

BFM-2004

CR

No

BM, TL

19

18

Pos

ND

KMT2A-MLLT1

Interfant-99

CR

No

BM

21

19

Pos

ND

KMT2A-MLLT10

Interfant-99

CR

No

No

32

20

Pos

ND

KMT2A-MLLT5

ALLIC-09

CR

No

No

21

21

Pos

ND

KMT2A-MLLT3

BFM like

CR

Sible-HSCT

No

108

22

Pos

Neg

KMT2A-MLLT3

KMT2A03

CR

mismatched-CBT

No

72

23

ND

ND

KMT2A-MLLT3

BFM-95

CR

MUD-CBT

No

12

24

ND

Neg

KMT2A-MLLT3

B-NHL-2010

CR

No

CNS

13

  1. ND, no data; Pos, positive; Neg: negative; HSCT, haematopoietic stem cell transplantation; CBT, cord blood transplant; MUD, matched unrelated donor; BM, bone marrow; TL, testicular leukaemia; CNS, central nervous system; EFS, event-free survival; OS, overall survival
  2. aTranscripts of KMT2Ar were detected by RT-PCR except for patient 2, who was tested by Northern Blot