Mature B cell acute lymphoblastic leukaemia with KMT2A-MLLT3 transcripts in children: three case reports and literature reviews

Table 4 FAB type, FCM and chromosomal karyotyping of BAL with KMT2Ar according to the literature review

Pt	FAB	Gender	CD19	sIgM	Light chain	CD10	CD20	CD22	TdT	CD34	Chromosomal karyotype
1	L1	F	Pos	Pos	L	Neg	Pos	ND	Pos	ND	46,XX(30)/46,XX, 11,t(4,?)(q35;?),t(9,11)(p22;q23),+der(ll)t(l;ll)(q21;q14)(6)
2	L1	F	+	Pos	L	Neg	Pos	Pos	ND	Neg	46,XX(4)/46,XX, t(9;11)(p21-22;q23)(12)
3	L1	M	+	Pos	L	Neg	−/+	Pos	Neg	Neg	Normal
4	L1	F	+	Pos	L	Neg	−/+	Pos	Neg	Neg	Normal
5	Non-L3	F	+	Pos	K	Neg	Pos	Pos	Neg	Neg	46,XX(30)
6	Non-L3	M	+	Pos	L	Neg	−/+	Pos	Neg	Neg	Normal
7	Non-L3	F	+	Pos	L	Neg	−/+	Pos	Neg	Neg	Normal
8	Non-L3	F	+	Pos	L	Neg	−/+	Pos	Neg	Neg	46,XX[4]/46,XX, t(9;11)(p21–22;q23)[12]
9	Non-L3	F	+	Pos	K	Pos	−/+	Pos	Neg	Neg	46,XX[30]
10	Non-L3	M	+	Pos	L	Neg	−/+	Pos	Neg	Neg	46,XX[20].ish add(11)(q23)[20
11	Non-L3	F	+	Neg	L	Neg	ND	Pos	Neg	Neg	46,XX[14].ish t(9;11)(p22;q23)
12	Non-L3	M	+	Pos	K	Neg	Neg	Pos	Neg	Neg	46,XY[10].ish t(9;11)(p22;q23)[15]
13	L1	F	+	Pos	K	Pos	ND	ND	Neg	Neg	46,XX
14	L1	M	+	Pos	Pos	Pos	Neg	Pos	Neg	Neg	46,XY[16]/46,XX,t(9;11;11)(p22;q23;p11.2)[4]
15	ALL-L3	M	−/+	Pos	Pos	Pos	−/+	Pos	−/+	Neg	46,XY,t(11;15)(q23;q15)[10]/46,XY[10]
16	L1	M	+	Pos	L	Neg	Pos	Pos	Neg	Pos	No metaphases
17	Non-L3	M	+	Pos	L	Pos	Pos	ND	Neg	Neg	46,XY,der(2),t(10;11)(p12;q23)[5]
18	L1	M	+	Pos	L	Neg	Neg	Pos	Neg	Neg	46–48,XY,+11,del(11)(q23),
19	L1	F	+	Pos	L	Pos	Neg	Pos	Pos	Pos	46,XX,add(9)(p24),ins(10;11)
20	L1	F	+	Pos	L	Pos	Neg	Pos	Pos	Pos	46,XX[20]
21	L1	F	+	Pos	ND	Pos	Pos	ND	ND	Neg	No metaphases
22	L1	F	+	Pos	ND	Pos	Pos	Pos	Neg	Neg	Normal
23	L1	F	+	Pos	ND	Pos	Neg	Pos	ND	Neg	ND
24	L2	M	+	Pos	L	Neg	Neg	ND	Neg	Neg	46,XY(3)

ND: No data; Pos: Positive; Neg: negative; L: Lambda chain; K: Kappa chain; Normal: reported normal chromosomal karyotype, but exact data were not presented

ISSN: 1750-1172