Skip to main content

Table 1 Patients’s demographics and clinical characteristics; *mean Hb in TDT refers to pre transfusional values; LIC: liver iron concentration; DFO: Deferoxamine; DFP: Deferiprone; DFX: Deferasirox

From: Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia

 

TDT

(n = 54)

NTDT

(n = 23)

All Patients

(n = 77)

Controls

(n = 56)

mean age, years

36.4 ± 9.2

30.3 ± 11.5

34.6 ± 10.5

33.9 ± 10.8

Females, n(%)

34 (62.9)

13 (56%)

47 (61.0)

36 (64.3)

Splenectomized, n (%)

35 (64.8)

9 (39%)

44 (57.1)

0

Hb*(g/dl), mean ± SD

9.2 ± 0.5

9.3 ± 0.9

9.3 ± 0.8

NA

Hb at MRI (g/dl), mean ± SD

9.6 ± 1.1

9.3 ± 0.9

9.5 ± 1

NA

Ferritin (ng/ml), mean ± SD

877.0 ± 684.4

364.1 ± 290.8

736.2 ± 641.7

NA

LIC (mg/gdw), mean ± SD

4.3 ± 3.0

6.7 ± 5.4

4.9 ± 3.7

NA

Iron Chelation Therapy

DFO ever, n (%)

50 (92.6)

6 (26.1)

56 (72.7)

0

ongoing, n (%)

14 (25.9)

2 (8.7)

16 (20.8)

0

current dose, mg/kg

35.8 ± 3.0

20.0 ± 1.6

33.5 ± 6.4

0

DFP ever, n (%)

21 (38.9)

0

21 (27.3)

0

ongoing, n (%)

4 (7.4)

0

5 (6.5)

0

current dose, mg/kg

73.6 ± 2.4

0

73.6 ± 2.4

0

DFX ever, n (%)

50 (92.6)

8 (34.8)

58 (75.3)

0

ongoing, n (%)

35(64.8)

4 (17.4)

38 (49.3)

0

current dose, mg/kg

27.8 ± 8.1

10.1 ± 0.6

21.5 ± 10.4

0