Table 4 Neurodevelopmental status assessment by age group (Wechsler preschool and primary scale of intelligence; ITTE population)
Timepoint | Statistics | ‘sapropterin continuous’ (n=25) | ‘sapropterin extension’ (n = 26) | ||||
|---|---|---|---|---|---|---|---|
Age | |||||||
< 12 Months | 12–< 24 Months | 24–< 48 Months | < 12 Months | 12–< 24 Months | 24–< 48 Months | ||
Full scale IQ (Wechsler scale of intelligence) | |||||||
Baseline | n (missing) | 0 (7) | 0 (9) | 2 (7) | 0 (8) | 1 (9) | 0 (8) |
Mean (SD) | – | – | 115.50 (17.68) | – | 124.00 | – | |
Month 12 | n (missing) | 0 (7) | 0 (9) | 9 (0) | 0 (8) | 7 (3) | 0 (8) |
Mean (SD) | – | – | 110.44 (17.58) | – | 111.43 (26.22) | – | |
Month 24 | n (missing) | 0 (7) | 3 (6) | 4 (5) | 0 (8) | 4 (6) | 5 (3) |
Mean (SD) | – | 98.00 (20.07) | 105.50 (12.12) | – | 115.25 (7.27) | 94.40 (19.69) | |
EOS | n (missing) | 6 (1) | 1 (8) | 4 (5) | 5 (3) | 5 (5) | 4 (4) |
Mean (SD) | 120.67 (14.67) | 94.00 | 95.25 (8.26) | 108.60 (14.81) | 108.20 (14.75) | 88.25 (14.17) | |
Performance IQ (Wechsler scale of intelligence) | |||||||
Baseline | n (missing) | 0 (7) | 0 (9) | 2 (7) | 0 (8) | 1 (9) | 0 (8) |
Mean (SD) | – | – | – | 114.00 | – | ||
Month 12 | n (missing) | 0 (7) | 0 (9) | 9 (0) | 0 (8) | 7 (3) | 0 (8) |
Mean (SD) | – | – | – | 96.43 (20.26) | – | ||
Month 24 | n (missing) | 0 (7) | 3 (6) | 4 (5) | 0 (8) | 4 (6) | 5 (3) |
Mean (SD) | – | 92.33 (22.01) | 105.25 (4.99) | – | 111.00 (12.19) | 95.40 (22.79) | |
EOS | n (missing) | 6 (1) | 1 (8) | 4 (5) | 5 (3) | 5 (5) | 4 (4) |
Mean (SD) | 116.33 (15.28) | 90.00 | 93.75 (11.24) | 96.80 (13.41) | 103.40 (18.17) | 89.75 (15.41) | |