Table 1 Classification and evaluation of participants
From: Endophenotypical drift in Huntington’s disease: a 5-year follow-up study
| Clinical evaluation | UHDRS total motor score (TMS) | |
|---|---|---|
| Pre-manifest: TMS ≤ 5 | Manifest: TMS > 5 | |
|
Neuropsychiatric evaluation Allocation to neuropsychiatric group if at least one criterion is met | 1. Usage of psychotropic medication on neuropsychiatric indication | |
| 2. A SCL-90-R GSI T-score ≥ 63 or a T-score ≥ 63 in more than two of the nine primary symptom dimensions. The SCL-90-R cut-offs are based on SCL-90-R guide | ||
| 3. A HAM-17 score ≥ 13 (moderate to severe depression) | ||
|
Cognitive evaluation Cognitively impaired if | Pre-morbid intellectual level: | Wechsler Adult Intelligence Scale (WAIS) |
| Danish adult reading test (DART) | ||
| A. four or more test performances were impaired | Memory: | Selective reminding test |
| Rey complex figure text | ||
| B. all tests in a domain (except psychomotor speed/attention) were impaired | Psychomotor speed/attention: | Trail making test A & B |
| SDMT | ||
| Executive functions: | Stroop test (100 items − incongruent)) | |
| Verbal fluency tests (category fluency (animals, 1 min), lexical fluency (s-words and a-words, 1 min)) | ||
| C. performances on all tests in the psychomotor speed/attention domain, and at least one other test was below cut-off | Visiospatial functions: | Rey complex figure |
| Ravens progressive matrices (set 1) | ||
| Block design test (modified version) | ||