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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Biochemical and molecular features of Chinese patients with glutaric acidemia type 1 detected through newborn screening

Fig. 2

Three-dimensional modeling structure analysis of wild-type and mutant products of GCDH. Green dashed lines represent hydrogen bonds, and the green number indicates hydrogen bond distances. Protein modeling showed that variant c.1016T>C (p.Met339Thr) increased hydrogen bonds between the protein position 335 and 339, which may affect the structure and function of the GCDH protein by altering the folding process

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172