Fig. 2
From: Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy
a Baseline analysis of CSF CHIT1 levels comparing diseased individuals to controls. Horizontal line shows median, whiskers illustrate interquartile range (0.25–0.75), each icon represents an individual patient, grey area marks range below the lower limit of quantification (563 pg/mL); ****p < 0.0001 calculated by Mann–Whitney U test. b Correlation between patients’ height and CSF CHIT1 levels before treatment initiation; each icon represents an individual patient; *p < 0.05 calculated by Spearman's rank-order correlation. CSF, cerebrospinal fluid; CHIT1, Chitotriosidase 1