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Table 2 Engraftment and GVHD

From: Haploidentical haematopoietic stem cell transplantation for malignant infantile osteopetrosis and intermediate osteopetrosis: a retrospective analysis of a single centre

Overall survival (%) 73.9%
Engraftment source  
 Father 19 (70.4)
 Mother 8 (29.6)
HLA-matched  
 5/10 (3/6) 18 (66.7)
 6/10 2 (7.4)
 7/10 4 (14.8)
 5/6 2 (7.4)
 9/10 1 (3.7)
Conditioning regimen  
 TBI (12) + Cy (120) 1
 Flu (120–150) + Bu (16–19.2) + Cy (200) 26
Blood type  
 Matched 12
 Mismatched 15
Stem cells infused  
 MNC × 108/kg 23.12 (10.04–51.90)
 CD34+  × 106/kg 10.22 (5.96–24.88)
aGVHD (%) 21/27 (77.8)
 Stage I–II 20
 Stage III 1
 Stage IV 0
cGVHD (%) 11/27 (40.7)
Infection  
 CMV infection (dead/alive) 0/15
 EBV infection, reactivated 10
 Bacterial 12
Haemorrhagic cystitis 3
HVOD (%) 5 (18.5)
Engraftment failure 0
  1. TBI, total body irradiation; Cy, cyclophosphamide; Flu, fludarabine; Bu, busulfan; GVHD, graft versus host disease; HVOD, hepatic veno-occlusive disease