Skip to main content

Table 2 Engraftment and GVHD

From: Haploidentical haematopoietic stem cell transplantation for malignant infantile osteopetrosis and intermediate osteopetrosis: a retrospective analysis of a single centre

Overall survival (%)

73.9%

Engraftment source

 

 Father

19 (70.4)

 Mother

8 (29.6)

HLA-matched

 

 5/10 (3/6)

18 (66.7)

 6/10

2 (7.4)

 7/10

4 (14.8)

 5/6

2 (7.4)

 9/10

1 (3.7)

Conditioning regimen

 

 TBI (12) + Cy (120)

1

 Flu (120–150) + Bu (16–19.2) + Cy (200)

26

Blood type

 

 Matched

12

 Mismatched

15

Stem cells infused

 

 MNC × 108/kg

23.12 (10.04–51.90)

 CD34+  × 106/kg

10.22 (5.96–24.88)

aGVHD (%)

21/27 (77.8)

 Stage I–II

20

 Stage III

1

 Stage IV

0

cGVHD (%)

11/27 (40.7)

Infection

 

 CMV infection (dead/alive)

0/15

 EBV infection, reactivated

10

 Bacterial

12

Haemorrhagic cystitis

3

HVOD (%)

5 (18.5)

Engraftment failure

0

  1. TBI, total body irradiation; Cy, cyclophosphamide; Flu, fludarabine; Bu, busulfan; GVHD, graft versus host disease; HVOD, hepatic veno-occlusive disease