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Table 2 Characteristics of the 9 patients of the Hendaye’s cluster

From: Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients

Patient

Genetic

BMI

Comorbidities

Treatments at the time of infection

Clinical signs

Treatments of COVID-19

Age

Subtype

(kg/m2)

Anticoagulants

O2

Antibiotics

Corticosteroids

P1;

45 years

Deletion

61.7

T2D; Hypertension; sleep apnea syndrome; Respiratory and cardiac failure; Lower limbs edema; past venous thrombotic events

Thyroxine

Antidiabetics

Antihypertensives

Fever, asthenia, headache, cough, shortness of breath, oxygen desaturation

Enoxaparin 0.6 ml * 2/day

Yes

amoxicillin/ clavulanic acid 1 g * 3 /day

DXM

6 mg/day for 12 days

P2;

60 years

Deletion

57.9

T2D; Hypertension; sleep apnea syndrome; Respiratory failure; Lower limbs edema; past venous thrombotic events

Thyroxine

Vitamin D

Antidiabetics

Antihypertensives

Cough, shortness of breath

Enoxaparin 0.6 ml * 2/day

Yes

amoxicillin/ clavulanic acid 1 g * 3 /day

DXM

6 mg/day for 12 days

P3;

40 years

Deletion

70.8

Hypertension; sleep apnea syndrome; Respiratory and cardiac failure; Lower limbs edema; past venous thrombotic events

Thyroxine

Vitamin D

Antihypertensives

Anxiolytics

Cough,

headache, shortness of breath

Enoxaparin 0.6 ml * 2/day

Yes

No

No

P4;

22 years

Deletion

47.7

T2D; sleep apnea syndrome; Respiratory failure; Lower limbs edema

Thyroxine

Antidiabetics

Topiramate

Antipsychotics

Fever, asthenia, shortness of breath

Enoxaparin 0.4 ml * 2/day

No

No

No

P5;

42 years

Deletion

39.9

T2D; Hypertension;

Sleep apnea syndrome; Lower limbs edema

Antidiabetics

Antihypertensives

Lipid lowering therapy

Topiramate; antidepressants

Cough

shortness of breath

Enoxaparin 0.4 ml * 2/day

No

No

No

P6;

33 years

UPD

32.0

 

Vitamin D

Antipsychotics; mood stabilisers

Fever, cough

Enoxaparin 0.4 ml * 2/day

No

No

No

P7;

21 years

Deletion

44.0

T2D

GH; SHT; Thyroxine

Antidiabetics

Antipsychotics

Antidepressants; Anxiolytics

Asymptomatic

Enoxaparin 0.4 ml * 2/day

No

No

No

P8;

52 years

Deletion

31.5

 

Vitamin D

Asymptomatic

Enoxaparin 0.4 ml * 2/day

No

No

No

P9;

29 years

Deletion

26.4

 

GH; SHT; Thyroxine

Vitamin D

Asymptomatic

Enoxaparin 0.4 ml * 2/day

No

No

No

  1. UPD Uniparental disomy, BMI Body Mass Index, T2D Type 2 diabetes, GH Growth Hormone, SHT Sex Hormone Therapy, O2 oxygen therapy, DXM dexamethasone