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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Cholbam® and Zellweger spectrum disorders: treatment implementation and management

Fig. 3

Heubi et al. [19]: impact of cholic acid therapy on bile acid levels, liver chemistry, and height and weight. ALT, alanine transaminase; AST aspartate transaminase; NS, not significant; SED, single enzyme defect; SEM, standard erroor of the mean; ULN, upper limit of normal. A Impact of cholic acid treatment on urinary bile acid excretion patients with Zellweger spectrum disorder (ZSD) (n = 27)—worst-to-best analysis, modified intent-to-treat (mITT) population. B Impact of cholic acid treatment on liver chemistries in patients with ZSD (n = 27)—worst-to-best analysis, mITT population. C Mean height and weight percentiles from pretreatment to post-treatment in the mITT population (N = 70), worst-to-best analysis. Numbers in bars represent absolute percentiles for each group. Reprinted from Heubi et al. [19]. This is an open access article distributed under the terms of the Creative Commons CCBY-NC-ND license, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal

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