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Table 1 Dysregulated downstream effectors in RASopathies based on immunoblotting

From: Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins

RASopathy Up Down
CFC AKT1 ERK1 ERK2 AKT1 ERK1 ERK2 VEGFR2
CS AKT1 ERK1 ERK2 P53 RAF1 nd
JMML ERK1 ERK2 STAT5A nd
LS ERK1 ERK2 RAF1
NF1 ERK1 ERK2 Synapsin-1 DPYSL2
NS AKT1 BRAF ERK1 ERK2 FAK1 FER GSK-3α IGF1R INSR JNK1 MEK1 MPZL1 P70S6K1 PECA1 RAF1 SHPS1 STAT5 VEGFR2 ANT1 GluN2B MEK1 RAF1
NSL p90RSK3 S6K-alpha-1 S6K-alpha-2 nd
NSLSH nd ERK1 RAF1
NSML AKT1 BRAF CAV2 EGFR ERK1 ERK2 FAK1 FER GSK-3α IGF1R INSR JNK1 MEK1 MPZL1 P70S6K1 PECA1 RAF1 SHPS1 STAT3 Tuberin ERK1 ERK2 LKC MEK1 P70S6K1 RAF1 Vinculin