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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins

Fig. 4

Analysis of dysregulated phosphosites in RASopathy interactome proteins in NS, NSML. A Heatmap representing the log2 (fold change) of phosphosites in NS and NSML versus control. Clustering analysis of the dysregulated phosphosites identified in phosphoproteomics and within the RASopathy interactome in either NS or NSML. An asterisk is added to zero values representing reported non-altered phosphorylation levels, to distinguish them from those representing just lack of data. In case of duplicated quantitative values from different studies, ‘ symbol was added [91]. B GO Biological processes overrepresentation test results using the 33 unique UniProt IDs from human dysregulated phosphosites reported in the RASopathy interactome on PANTHER

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172