Skip to main content
Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins

Fig. 2

Association map of the 32 RASopathy proteins used in this study. Only 27 are shown since the RAS node includes HRAS, KRAS and NRAS, the RRAS node includes RRAS, RRAS2 and MRAS, and the MEK1/2 node includes MEK1 and MEK2. The thickness of the lines indicates the strength of data support according to STRING database. A Association map of the 32 RASopathy proteins used in this study. Corresponding proteins are shown in the figure. RAS includes six Ras proteins, whereas MEK1 and MEK2 are represented as MEK1/2. The thickness of the lines indicates the strength of data support according to STRING database. B Overlap of the interactome among the 32 RASopathy proteins. From left to right, protein names, number of direct partners, number of partners associated with other RASopathy proteins, and percentage of overlap. Last column indicates whether or not they interact with RAS/MAPK. Direct partners for each protein (N), were obtained from the interactome generated in this study including 27 RASopathy proteins and their neighbors (listed in Table S1)

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172