Skip to main content

Table 1 Complications associated with PIK3CA-related disorders [1, 3, 9, 42, 50, 52]

From: A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations

Severe functional impairment
Vascular complications
 Coagulopathy or changes in coagulation
  Chronic consumptive coagulopathy
  Localized intravascular coagulopathy
Neurologic complications
 Ventriculomegaly or hydrocephalus
 Cerebellar tonsillar ectopia
 Brainstem compression
 Developmental delay
Risk of malignant tumors
 Wilms’ tumor
Dermatologic, genitourinary, gastrointestinal, or endocrine/metabolism involvement