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Table 1 Complications associated with PIK3CA-related disorders [1, 3, 9, 42, 50, 52]

From: A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations

Severe functional impairment
Pain
Vascular complications
 Coagulopathy or changes in coagulation
  Chronic consumptive coagulopathy
  Localized intravascular coagulopathy
 Hemorrhage
 Thromboembolism
Infections
Neurologic complications
 Ventriculomegaly or hydrocephalus
 Cerebellar tonsillar ectopia
 Brainstem compression
 Seizures
 Developmental delay
 Hypotonia
Risk of malignant tumors
 Wilms’ tumor
 Leukemia
 Meningiomas
Dermatologic, genitourinary, gastrointestinal, or endocrine/metabolism involvement