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Table 2 Discriminating ability of the fractions of lymphocytes with small and round nuclei

From: Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis

  Fractions of lymphocytes with
small area and low radius ratio small area and increased roundness short perimeter and low radius ratio short perimeter and increased roundness
Cutoff value 16.4% 23.0% 14.0% 21.9%
Development cohort     
Sensitivity 0.944 0.944 0.944 0.889
Specificity 0.820 0.780 0.800 0.820
Accuracy 0.853 0.824 0.838 0.838
Validation cohort     
AUROC (95% CI.) 0.938 (0.865–1.000) 0.922 (0.847–0.998) 0.933 (0.857–1.000) 0.928 (0.832–1.000)
Sensitivity 1.000 1.000 1.000 1.000
Specificity 0.711 0.622 0.733 0.711
Accuracy 0.755 0.679 0.774 0.755
  1. AUROC, area under the ROC curve; CI, confidence interval