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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis

Fig. 5

BALF CD4/CD8 ratios in sarcoidosis and in the other ILDs. a BALF CD4/CD8 ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 7.75ā€‰Ā±ā€‰0.95, 4.66ā€‰Ā±ā€‰0.98, 6.25ā€‰Ā±ā€‰1.7, 0.960ā€‰Ā±ā€‰0.34, 1.28ā€‰Ā±ā€‰0.26, and 2.67ā€‰Ā±ā€‰0.65, respectively. The horizontal bars represent the mean values. The p value for the Kruskalā€“Wallis test is shown on the upper right corner. * the p value for the Mannā€“Whitney U test is under a significance level set at Ī±ā€‰=ā€‰0.010 (five comparisons in five groups). b The ROC curve for the BALF CD4/CD8 ratio revealed an AUROC of 0.844 (95% confidence interval 0.749ā€“0.940, pā€‰<ā€‰0.001) in distinguishing sarcoidosis. c Scatterplots representing the correlations between CD4/CD8 ratio and the fraction of lymphocytes with small and round nuclei defined as follows: small nuclear area and low radius ratio (upper left, pā€‰=ā€‰0.390, R2ā€‰=ā€‰0.047), small nuclear area and increased roundness (upper right, pā€‰=ā€‰0.425, R2ā€‰=ā€‰0.040), short nuclear perimeter and low radius ratio (lower left, pā€‰=ā€‰0.362, R2ā€‰=ā€‰0.052), and short nuclear perimeter and increased roundness (lower right, pā€‰=ā€‰0.387, R2ā€‰=ā€‰0.047). HP, hypersensitivity pneumonia; NSIP, nonspecific interstitial pneumonia; COP, cryptogenic organizing pneumonia; DILD, drug-induced interstitial lung disease; CTD-ILD, connective-tissue disease associated interstitial lung disease; ROC, receiver operating characteristic; AUROC: area under the ROC curve

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