Fig. 5From: Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosisBALF CD4/CD8 ratios in sarcoidosis and in the other ILDs. a BALF CD4/CD8 ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 7.75āĀ±ā0.95, 4.66āĀ±ā0.98, 6.25āĀ±ā1.7, 0.960āĀ±ā0.34, 1.28āĀ±ā0.26, and 2.67āĀ±ā0.65, respectively. The horizontal bars represent the mean values. The p value for the KruskalāWallis test is shown on the upper right corner. * the p value for the MannāWhitney U test is under a significance level set at Ī±ā=ā0.010 (five comparisons in five groups). b The ROC curve for the BALF CD4/CD8 ratio revealed an AUROC of 0.844 (95% confidence interval 0.749ā0.940, pā<ā0.001) in distinguishing sarcoidosis. c Scatterplots representing the correlations between CD4/CD8 ratio and the fraction of lymphocytes with small and round nuclei defined as follows: small nuclear area and low radius ratio (upper left, pā=ā0.390, R2ā=ā0.047), small nuclear area and increased roundness (upper right, pā=ā0.425, R2ā=ā0.040), short nuclear perimeter and low radius ratio (lower left, pā=ā0.362, R2ā=ā0.052), and short nuclear perimeter and increased roundness (lower right, pā=ā0.387, R2ā=ā0.047). HP, hypersensitivity pneumonia; NSIP, nonspecific interstitial pneumonia; COP, cryptogenic organizing pneumonia; DILD, drug-induced interstitial lung disease; CTD-ILD, connective-tissue disease associated interstitial lung disease; ROC, receiver operating characteristic; AUROC: area under the ROC curveBack to article page