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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis

Fig. 5

BALF CD4/CD8 ratios in sarcoidosis and in the other ILDs. a BALF CD4/CD8 ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 7.75 ± 0.95, 4.66 ± 0.98, 6.25 ± 1.7, 0.960 ± 0.34, 1.28 ± 0.26, and 2.67 ± 0.65, respectively. The horizontal bars represent the mean values. The p value for the Kruskal–Wallis test is shown on the upper right corner. * the p value for the Mann–Whitney U test is under a significance level set at α = 0.010 (five comparisons in five groups). b The ROC curve for the BALF CD4/CD8 ratio revealed an AUROC of 0.844 (95% confidence interval 0.749–0.940, p < 0.001) in distinguishing sarcoidosis. c Scatterplots representing the correlations between CD4/CD8 ratio and the fraction of lymphocytes with small and round nuclei defined as follows: small nuclear area and low radius ratio (upper left, p = 0.390, R2 = 0.047), small nuclear area and increased roundness (upper right, p = 0.425, R2 = 0.040), short nuclear perimeter and low radius ratio (lower left, p = 0.362, R2 = 0.052), and short nuclear perimeter and increased roundness (lower right, p = 0.387, R2 = 0.047). HP, hypersensitivity pneumonia; NSIP, nonspecific interstitial pneumonia; COP, cryptogenic organizing pneumonia; DILD, drug-induced interstitial lung disease; CTD-ILD, connective-tissue disease associated interstitial lung disease; ROC, receiver operating characteristic; AUROC: area under the ROC curve

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