Fig. 4

Fractions of lymphocytes with small and round nuclei. a The fractions (%) of lymphocytes with small nuclear areas and low radius ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 32.3 ± 3.4, 14.8 ± 2.0, 15.0 ± 9.3, 8.5 ± 2.4, 7.9 ± 2.2, and 11.4 ± 1.8, respectively. b The fractions (%) of lymphocytes with small nuclear areas and increased roundness in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 43.7 ± 4.0, 22.5 ± 2.9, 21.4 ± 1.0, 15.7 ± 2.5, 11.8 ± 3.1, and 17.4 ± 2.1, respectively. c The fractions (%) of lymphocytes with short nuclear perimeters and low radius ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 29.5 ± 3.5, 12.1 ± 2.0, 12.4 ± 9.4, 7.3 ± 2.8, 6.5 ± 1.6, and 9.0 ± 1.3, respectively. d The fractions (%) of lymphocyte with short nuclear perimeters and increased roundness in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 39.8 ± 4.4, 18.5 ± 2.8, 18.0 ± 11.0, 14.1 ± 3.0, 90.4 ± 2.4, and 13.1 ± 1.7, respectively. The horizontal bars represent the mean values. The p value for the Kruskal–Wallis test is shown on the upper right corner of each chart. *The p value for the Mann–Whitney U test is under a significance level set at α = 0.010 (five comparisons in five groups). HP, hypersensitivity pneumonia; NSIP, nonspecific interstitial pneumonia; COP, cryptogenic organizing pneumonia; DILD, drug-induced interstitial lung disease; CTD-ILD, connective-tissue disease associated interstitial lung disease