Fig. 3

Fractions of lymphocyte with small or round nucleus. a The fractions (%) of lymphocytes with small nuclear areas in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 66.8 ± 4.7, 49.6 ± 5.1, 35.7 ± 1.4, 51.0 ± 6.8, 25.4 ± 5.0, and 35.3 ± 4.4, respectively. b The fractions (%) of lymphocytes with short nuclear perimeters in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 53.7 ± 5.3, 32.1 ± 4.3, 25.1 ± 1.4, 28.3 ± 6.4, 14.0 ± 3.4, and 20.6 ± 2.5, respectively. c The fractions (%) of lymphocytes with low nuclear radius ratios in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 44.4 ± 2.9, 28.6 ± 2.6, 33.2 ± 6.0, 17.8 ± 2.7, 23.2 ± 2.7, and 27.6 ± 3.2, respectively. d The fractions (%) of lymphocytes with increased nuclear roundness in sarcoidosis, HP, NSIP, COP, DILD, and CTD-ILD were 58.4 ± 3.4, 40.1 ± 2.8, 46.8 ± 6.4, 28.3 ± 2.8, 30.4 ± 2.9, and 39.9 ± 4.0, respectively. The horizontal bars represent the mean values. The p value for the Kruskal–Wallis test is shown on the upper right corner of each chart. *the p value for the Mann–Whitney U test is under a significance level set at α = 0.010 (five comparisons in five groups). HP, hypersensitivity pneumonia; NSIP, nonspecific interstitial pneumonia; COP, cryptogenic organizing pneumonia; DILD, drug-induced interstitial lung disease; CTD-ILD, connective-tissue disease associated interstitial lung disease