Table 4 Main clinical and immunohematological characteristics of Dercum’s disease (DD) and Roch-Leri lipomatosis (LMS) groups compared to an obese control group
Metabolic characteristics | Dercum(n = 9) | LMS(n = 11) | Obese controls(n = 8) | p DD versus obese | p LMS versus obese | p obese versus lean |
|---|---|---|---|---|---|---|
Clinical data | ||||||
Sex ratio (M/W) | 0.5 (3 M/6F) | 1.75 (7 M/4F) | 0.5 (4 M/4F) | > 0.99 | > 0.99 | 0.09 |
Age (years) | 30.8 [16–50] | 31.2 [18–68] | 46.5 [23–64] | 0.44 | 0.21 | > 0.99 |
BMI (kg/m2) | 32 [27–59] | 31 [25–35] | 34.1 [31–43] | > 0.99 | > 0.99 | 0.002 |
Treated hypertension (%; n/N) | 22% (2/9) | 64% (7/11) | 38%(3/8) | > 0.99 | > 0.99 | 0.27 |
Diabetes (%; n/N) | 33% (3/9) | 9% (1/11) | 25% (2/8) | > 0.99 | > 0.99 | 0.75 |
Treated dyslipidemia (%; n/N) | 11% (1/9) | 45% (5/11) | 38% (3/8) | > 0.99 | > 0.99 | 0.22 |
Paraclinica | ||||||
Hemoglobin (g/dL) | 14.3 [12.5–15.4] | 14.6 [12–15.4] | 14.9[12.8–16.6] | 0.47 | > 0.99 | > 0.99 |
Platelets (103/mm3) | 266 [211–310] | 220 [104–255] | 242 [221–283] | 0.8 | 0.51 | 0.09 |
Leukocytes (103/mm3) | 7.8 [5–9.1] | 5.8 [5.2–9.8] | 6.9 [5.1–11.3] | 0.97 | 0.74 | 0.06 |
CRP (mg/L) | 3 [3–18] | 3 [3–10] | 6.3 [3–10] | > 0.99 | > 0.99 | > 0.99 |
Leukocyte differential: (/mm3) | ||||||
Lymphocytes | 1939 [1100–2000] | 1832 [600–2300] | 2141 [1500–3300] | 0.71 | 0.46 | 0.97 |
Monocytes | 500 [500–700] | 400`[400–600] | 400 [300–700] | > 0.99 | > 0.99 | > 0.99 |
Nuclear neutrophils | 5200 [2600–10000] | 3300 [2500–4600] | 4050 [2600–7100] | > 0.99 | > 0.99 | 0.16 |
Eosinophils | 150 [0–300] | 100 [0–500] | 188 [100–400] | > 0.99 | 0.35 | > 0.99 |
Basophils | 52 [30–100] | 19 [0–37] | 22 [0–100] | 0.03 | 0.97 | 0.14 |
Lymphocytes subpopulations (n/N) | (5/9) | (7/11) | (8/8) | |||
CD3+ | 1420 [1105–1904] | 867 [513–1584] | 1688[1215–1982] | 0.94 | 0.02 | 0.84 |
CD4+ | 1255 [790–1710] | 636.5 [328–922] | 979 [785–1454] | 0.96 | 0.01 | 0.77 |
CD8+ | 479 [454–788] | 227[140–310] | 493 [209–992] | > 0.99 | 0.02 | 0.89 |
B Lymphocytes | 204.5 [140–760] | 227 [101–310] | 199 [152–346] | 0.73 | > 0.99 | > 0.99 |
NK Lymphocytes | 207.5 [40–225] | 210 [124–300] | 287 [226–634] | 0.06 | 0.31 | > 0.99 |