Table 2 Main metabolic characteristics of patients belonging to the Dercum’s disease and Roch Leri lipomatosis (LMS) groups compared to the lean control group

Clinical data

Age (years)

30.8 [16–50]

31.2 [18–68]

32.8 [19–65]

Weight (kg)

89 [58–98]

100 [55–142]

69 [49–83]

BMI (kg/m²)

32.5 [27–59]

31 [25–35]

22 [17–25]

Systolic Blood Pressure (mmHG)

130 [130–160]

140 [115–150]

115 [103–146]

Diastolic Blood Pressure (mmHG)

78.6 [60–90]

79.7 [70–95]

72.5 [68–89]

Metabolic data

Triglycerides (g/L)

1.22 [0.65–9.42]

1.37 [0.74–2.63]

0.87 [0.56–2.77]

HDL-c (g/L)

0.45 [0.34–0.55]

0.48 [0.41–0.82]

0.53 [0.38–0.72]

LDL-c (g/L)

1.46 [0.83–2.72]

1.22 [0.91–1.87]

1.16 [0.92–1.4]

AST (IU/L)

27 [18–43]

25 [21–81]

22 [17–29]

ALT (IU/L)

26 [14–75]

28,5 [11–78]

17 [10–31]

Gamma-GT (IU/L)

83 [58–125]

74 [30–139]

18.7 [11–28]

Fasting blood glucose (g/L)

1 [0.92–1.33]

0.98 [0.84–1.32]

0.86 [0.77–1.01]

Fasting insulin (µIU/L; n/N)

8.1 [6.3–14-4] (7/9)

7.35 [6.3–35.8](7/11)^a

4.6 [1.2–9.2] (18/18)

Fasting C-peptide (ng/mL; n/N)

3.2 [2.46–4.33](7/9)

2.57 [1.57–5.21](7/11)^a

1.75 [1–3.7] (18/18)

HOMA-IR (n/N)

2.67 [1.02–4.2] (7/9)

1.67 [1.4–11.6](7/11)^a

1 [0.25–2.18](18/18)

Leptin (ng/mL)

47.9 [6.7–224]

28.5 [13–110.8]

5.1 [4.1–16.1]

Anthropometric data

Fat mass estimated in DEXA (%; n/N)

37.1 [27.9–44.5](6/9)

34.3 [31.5–42.8] (8/11)

22.9[17.9–34.9] (18/18)

Intra/total abdominal fat ratio (n/N)

0.36 [0.20–0.98](8/9)

0.31[0.24–0.6] (5/11)

0.19[0.10–0.60] (18/18)