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Table 2 Main metabolic characteristics of patients belonging to the Dercum’s disease and Roch Leri lipomatosis (LMS) groups compared to the lean control group

From: Metabolic and immunological phenotype of rare lipomatoses: Dercum’s disease and Roch-Leri mesosomatic lipomatosis

Metabolic characteristics Dercum (n = 9) LMS (n = 11) Lean controls (n = 18) p Dercum versus Lean p LMS versus Lean p Dercum versus LMS
Clinical data
Age (years) 30.8 [16–50] 31.2 [18–68] 32.8 [19–65] 0.35 0.16 0.69
Weight (kg) 89 [58–98] 100 [55–142] 69 [49–83] 0.01 0.001 0.42
BMI (kg/m2) 32.5 [27–59] 31 [25–35] 22 [17–25] 0.0005 0.0002 0.71
Systolic Blood Pressure (mmHG) 130 [130–160] 140 [115–150] 115 [103–146] 0.013 0.001 0.42
Diastolic Blood Pressure (mmHG) 78.6 [60–90] 79.7 [70–95] 72.5 [68–89] 0.04 0.04 0.93
Metabolic data
Triglycerides (g/L) 1.22 [0.65–9.42] 1.37 [0.74–2.63] 0.87 [0.56–2.77] 0.07 0.83 0.98
HDL-c (g/L) 0.45 [0.34–0.55] 0.48 [0.41–0.82] 0.53 [0.38–0.72] 0.17  > 0.99 0.15
LDL-c (g/L) 1.46 [0.83–2.72] 1.22 [0.91–1.87] 1.16 [0.92–1.4] 0.03 0.72 0.20
AST (IU/L) 27 [18–43] 25 [21–81] 22 [17–29] 0.05 0.09  > 0.9
ALT (IU/L) 26 [14–75] 28,5 [11–78] 17 [10–31] 0.05 0.09 0.72
Gamma-GT (IU/L) 83 [58–125] 74 [30–139] 18.7 [11–28] 0.0001 0.0001 0.54
Fasting blood glucose (g/L) 1 [0.92–1.33] 0.98 [0.84–1.32] 0.86 [0.77–1.01] 0.0028 0.057 0.27
Fasting insulin (µIU/L; n/N) 8.1 [6.3–14-4] (7/9) 7.35 [6.3–35.8](7/11)a 4.6 [1.2–9.2] (18/18) 0.004 0.014 0.68
Fasting C-peptide (ng/mL; n/N) 3.2 [2.46–4.33](7/9) 2.57 [1.57–5.21](7/11)a 1.75 [1–3.7] (18/18) 0.016 0.04 0.84
HOMA-IR (n/N) 2.67 [1.02–4.2] (7/9) 1.67 [1.4–11.6](7/11)a 1 [0.25–2.18](18/18) 0.0008 0.02 0.62
Leptin (ng/mL) 47.9 [6.7–224] 28.5 [13–110.8] 5.1 [4.1–16.1] 0.003 0.0002  > 0.9
Anthropometric data
Fat mass estimated in DEXA (%; n/N) 37.1 [27.9–44.5](6/9) 34.3 [31.5–42.8] (8/11) 22.9[17.9–34.9] (18/18) 0.008 0.004  > 0.9
Intra/total abdominal fat ratio (n/N) 0.36 [0.20–0.98](8/9) 0.31[0.24–0.6] (5/11) 0.19[0.10–0.60] (18/18) 0.04 0.03 0.87
  1. The number of patients studied was indicated only when at least one data point was missing: n: number of examinations performed/ N: total number of patients in the group
  2. aExclusion of diabetic patients
  3. *: p < 0.05, **: p < 0.01, ***: p < 0.001, ns: non significant; p > 0.05*: p < 0.05, **: p < 0.01, ***: p < 0.001, ns: non significant