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Table 7 Malignancies by organ class and age groups

From: Rare manifestations and malignancies in tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA)

Organs 5-year prevalence of malignancies in general population by age group (per 100, 000)$, 25   Age (years), n (%)   
0–9 10–14 15–19 20–39  > 40  ≤ 2
(n = 1)
 > 2– ≤ 5
(n = 3)
 > 5– ≤ 9
(n = 3)
 > 9– ≤ 14
(n = 8)
 > 14– ≤ 18
(n = 2)
 > 18– ≤ 40
(n = 24)
 > 40
(n = 24)
Kidney 2.1 0.48 0.51 1.7 34.3 1 (100) 3 (100) 2 (66.7) 3 (37.5) 1 (50.0) 10 (41.7) 11 (45.8)
Breast 0.02 1.2 7.7 46.5 450.5 0 0 0 0 0 1 (4.2) 6 (25)
Thyroid 0.28 4.3 9.5 20.6 54.4 0 0 0 1 (12.5) 1 (50.0) 1 (4.2) 3 (12.5)
Testis 0.97 3.1 6.7 12.0 9.2 0 0 0 0 0 4 (16.7) 1 (4.2)
Ovary 0.62 2.1 3.9 9.5 45.7 0 0 0 1 (12.5) 0 2 (8.3) 1 (4.2)
Brain 3.2 3.4 3.6 5.2 20.7 0 0 0 1 (12.5) 0 0 0
Colon 0.06 0.82 1.7 4.7 170.1 0 0 0 0 0 0 2 (8.3)
Bone, soft tissue 0 0 1 (33.3) 0 0 0 1 (4.2)
Pancreas 0.01 0.10 0.26 0.47 9.9 0 0 0 2 (25.0) 0 0 0
Lung 0.06 0.34 0.77 1.8 75.9 0 0 0 0 0 1 (4.2) 1 (4.2)
Skin* 0.11 0.70 1.7 4.2 31.4 0 0 0 0 0 1 (4.2) 0
Eye 0 0 0 0 0 1 (4.2) 0
Liver 0.72 0.49 0.84 1.8 22.4 0 0 0 0 0 1 (4.2) 0
  1. *Melanoma of skin. $5-year prevalence of malignancies have been presented for qualitative comparison between the general population and our cohort