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Table 7 Malignancies by organ class and age groups

From: Rare manifestations and malignancies in tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA)

Organs

5-year prevalence of malignancies in general population by age group (per 100, 000)$, 25

 

Age (years), n (%)

  

0–9

10–14

15–19

20–39

 > 40

 ≤ 2

(n = 1)

 > 2– ≤ 5

(n = 3)

 > 5– ≤ 9

(n = 3)

 > 9– ≤ 14

(n = 8)

 > 14– ≤ 18

(n = 2)

 > 18– ≤ 40

(n = 24)

 > 40

(n = 24)

Kidney

2.1

0.48

0.51

1.7

34.3

1 (100)

3 (100)

2 (66.7)

3 (37.5)

1 (50.0)

10 (41.7)

11 (45.8)

Breast

0.02

1.2

7.7

46.5

450.5

0

0

0

0

0

1 (4.2)

6 (25)

Thyroid

0.28

4.3

9.5

20.6

54.4

0

0

0

1 (12.5)

1 (50.0)

1 (4.2)

3 (12.5)

Testis

0.97

3.1

6.7

12.0

9.2

0

0

0

0

0

4 (16.7)

1 (4.2)

Ovary

0.62

2.1

3.9

9.5

45.7

0

0

0

1 (12.5)

0

2 (8.3)

1 (4.2)

Brain

3.2

3.4

3.6

5.2

20.7

0

0

0

1 (12.5)

0

0

0

Colon

0.06

0.82

1.7

4.7

170.1

0

0

0

0

0

0

2 (8.3)

Bone, soft tissue

0

0

1 (33.3)

0

0

0

1 (4.2)

Pancreas

0.01

0.10

0.26

0.47

9.9

0

0

0

2 (25.0)

0

0

0

Lung

0.06

0.34

0.77

1.8

75.9

0

0

0

0

0

1 (4.2)

1 (4.2)

Skin*

0.11

0.70

1.7

4.2

31.4

0

0

0

0

0

1 (4.2)

0

Eye

0

0

0

0

0

1 (4.2)

0

Liver

0.72

0.49

0.84

1.8

22.4

0

0

0

0

0

1 (4.2)

0

  1. *Melanoma of skin. $5-year prevalence of malignancies have been presented for qualitative comparison between the general population and our cohort