Organs | 5-year prevalence of malignancies in general population (per 100, 000)$, 25 | All, n (%) N = 65 | Sex, n (%) | Mutation, n (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Overall | Male | Female | Male (n = 23) | Female (n = 42) | p value | TSC1 (n = 11) | TSC2 (n = 15) | p value | ||
Kidney | 13.4 | 16.5 | 10.3 | 31 (47.7) | 11 (47.8) | 20 (47.6) | NS | 4 (36.4) | 8 (53.3) | 0.3176 |
Breast | 181.8 | – | 181.8 | 7 (10.8) | 0 | 7 (16.7) | 0.0159 | 1 (9.1) | 1 (6.7) | 0.3961 |
Thyroid | 26.2 | 11.2 | 41.4 | 6 (9.2) | 0 | 6 (14.3) | 0.0159 | 3 (27.3) | 1 (6.7) | 0.0104 |
Testis | 7.4 | 7.4 | – | 5 (7.7) | 5 (21.7) | 0 | 0.0265 | 1 (9.1) | 0 | 0.2230 |
Ovary | 20.2 | – | 20.2 | 4 (6.2) | NA | 4 (9.5) | NS | 1 (9.1) | 3 (20.0) | 1.000 |
Bone, soft tissue | – | – | – | 2 (3.1) | 2 (8.7) | 0 | NS | 0 | 1 (6.7) | 1.000 |
Colon | 62.8 | 67.4 | 58.0 | 2 (3.1) | 0 | 2 (4.8) | NS | 0 | 0 | NE |
Lung | 27.9 | 34.1 | 21.6 | 2 (3.1) | 0 | 2 (4.8) | NS | 1 (9.1) | 0 | 0.2230 |
Pancreas | 3.7 | 3.9 | 3.5 | 2 (3.1) | 2 (8.7) | 0 | NS | 0 | 1 (6.7) | 1.000 |
Brain (cerebral) | 10.1 | 10.3 | 9.9 | 1 (1.5) | 1 (4.3) | 0 | NS | 0 | 0 | NE |
Eye | – | – | – | 1 (1.5) | 0 | 1 (2.4) | NS | 0 | 0 | NE |
Liver | 8.8 | 12.2 | 5.4 | 1 (1.5) | 1 (4.3) | 0 | NS | 0 | 0 | NE |
Skin* | 12.7 | 13.1 | 12.2 | 1 (1.5) | 1 (4.3) | 0 | 0.4835 | 0 | 0 | NE |