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Table 6 Rate of malignancies in different organs in all patients, by sex and genotype

From: Rare manifestations and malignancies in tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA)

Organs 5-year prevalence of malignancies in general population (per 100, 000)$, 25 All, n (%)
N = 65
Sex, n (%)   Mutation, n (%)  
Overall Male Female Male
(n = 23)
Female
(n = 42)
p value TSC1
(n = 11)
TSC2
(n = 15)
p value
Kidney 13.4 16.5 10.3 31 (47.7) 11 (47.8) 20 (47.6) NS 4 (36.4) 8 (53.3) 0.3176
Breast 181.8 181.8 7 (10.8) 0 7 (16.7) 0.0159 1 (9.1) 1 (6.7) 0.3961
Thyroid 26.2 11.2 41.4 6 (9.2) 0 6 (14.3) 0.0159 3 (27.3) 1 (6.7) 0.0104
Testis 7.4 7.4 5 (7.7) 5 (21.7) 0 0.0265 1 (9.1) 0 0.2230
Ovary 20.2 20.2 4 (6.2) NA 4 (9.5) NS 1 (9.1) 3 (20.0) 1.000
Bone, soft tissue 2 (3.1) 2 (8.7) 0 NS 0 1 (6.7) 1.000
Colon 62.8 67.4 58.0 2 (3.1) 0 2 (4.8) NS 0 0 NE
Lung 27.9 34.1 21.6 2 (3.1) 0 2 (4.8) NS 1 (9.1) 0 0.2230
Pancreas 3.7 3.9 3.5 2 (3.1) 2 (8.7) 0 NS 0 1 (6.7) 1.000
Brain (cerebral) 10.1 10.3 9.9 1 (1.5) 1 (4.3) 0 NS 0 0 NE
Eye 1 (1.5) 0 1 (2.4) NS 0 0 NE
Liver 8.8 12.2 5.4 1 (1.5) 1 (4.3) 0 NS 0 0 NE
Skin* 12.7 13.1 12.2 1 (1.5) 1 (4.3) 0 0.4835 0 0 NE
  1. *Melanoma of skin. $5-year prevalence of malignancies have been presented for qualitative comparison between the general population and our cohort. NE, non-estimable; NS, not significant