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Table  5 Rate of the ten most common rare manifestations by age group

From: Rare manifestations and malignancies in tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA)

 

Age, years

n (%)

 ≤ 2

(n = 10)

2– ≤ 5

(n = 16)

 > 5– ≤ 9

(n = 23)

 > 9– ≤ 14 (n = 49)

 > 14– ≤ 18 (n = 18)

 > 18– ≤ 40 (n = 168)

 > 40

(n = 98)

Bone sclerotic foci

0

0

1 (4.3)

5 (10.2)

5 (27.8)

88 (52.4)

52 (53.1)

Scoliosis

1 (10)

2 (12.5)

8 (34.8)

24 (48.9)

6 (33.3)

37 (22.0)

10 (10.2)

Thyroid adenoma

0

0

0

1 (2.0)

1 (5.6)

8 (4.8)

11 (11.2)

Adrenal angiomyolipoma

0

0

4 (17.4)

2 (4.1)

0

8 (4.8)

3 (3.1)

pNET

0

0

1 (4.3)

3 (6.1)

0

7 (4.2)

1 (1.0)

Hemihypertrophy

3 (30)

1 (6.3)

1 (4.3)

1 (2.0)

2 (11.1)

3 (1.8)

1 (1.0)

Liver cysts

0

0

0

1 (2.0)

0

3 (1.8)

5 (5.1)

Spleen angiomyolipoma

0

2 (12.5)

0

2 (4.1)

0

2 (1.2)

3 (3.1)

Ovarian cysts

0

0

1 (4.3)

4 (8.2)

0

3 (1.8)

0

Lymphedema

1 (10)

0

0

2 (4.1)

1 (5.6)

1 (0.6)

2 (2.0)

Liver angiomyolipoma

0

0

0

1 (2.0)

0

3 (1.8)

2 (2.0)

  1. pNET, pancreatic neuroendocrine tumor