Table 1 Demographic characteristics in patients with and without rare manifestations and in patients with and without malignancies
Characteristics | Patients with rare manifestations, n (%) | Patients without rare manifestations, n (%) | p value | Patients with malignancies, n (%) | Patients without malignancies, n (%) | p value |
|---|---|---|---|---|---|---|
Age at consent, years | N = 382 | N = 1829 | N = 65 | N = 2146 | ||
Mean (SD) | 28.4 (16.71) | 15.0 (14.15) | < 0.0001 | 32.7 (18.86) | 16.9 (15.11) | < 0.0001 |
Median (range) | 26.0 (0–71) | 10.0 (0–71) | 31 (0–68) | 12 (0–71) | ||
Age at first TSC diagnosis, years | ||||||
Mean (SD) | 12.4 (16.68) | 5.8 (10.87) | < 0.0001 | 16.9 (18.94) | 6.6 (11.95) | < 0.0001 |
Median (range) | 2.0 (0–69) | 1.0 (0–67) | 10.5 (0–67) | 1 (0–69) | ||
Sex, n (%) | ||||||
Male | 159 (41.6) | 900 (49.2) | 0.007 | 22 (33.8) | 1036 (48.3) | 0.0214 |
Female | 223 (58.4) | 928 (50.8) | 43 (66.2) | 1109 (51.7) | ||
Mutation, n (%) | ||||||
TSC1 | 39 (21.1) | 152 (18.4) | NS | 10 (32.3) | 181 (18.5) | 0.0366 |
TSC2 | 124 (67.0) | 525 (63.6) | 15 (48.4) | 634 (64.7) | ||
NMI | 19 (10.3) | 129 (15.6) | 6 (19.4) | 142 (14.5) |