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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Gene expression analysis in EBV-infected ataxia-telangiectasia cell lines by RNA-sequencing reveals protein synthesis defect and immune abnormalities

Fig. 4

RNA seq results of the viral genome. a Whole genome view of RNA-seq coverage across the EBV genome on representative samples of LCL-WT and LCL-AT. The y-axis shows the number of reads mapping to each location of the EBV genome on a logarithmic scale. b Results of reads alignment on the viral genome. The number of normalized reads is indicated on the y-axis. c Normalized BZLF1 reads show the expression pattern as total normalized reads. d Normalized latent counts were extracted from total viral counts. e Heatmap displaying all latent genes in each LCL-WT and LCL-AT. Red represent downregulated genes and green represent upregulated genes. fh Analysis of EBV read counts from the 1000 genome project (1 k gen.). f 464 EBV RNA-seq results were separated in 4 groups according to the expression of BZLF1 (quantile Q1–Q4). For each of these quantile, total viral counts (G) and latent counts (H) were determinated. ***pval < 0.001

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