Direct and indirect costs and cost-driving factors of Tuberous sclerosis complex in children, adolescents, and caregivers: a multicenter cohort study

Table 5 Indirect costs to caregivers for a 3-month period (in 2019 Euro)

Indirect costs components	n¹	Mean costs	SD²	Median	Maximum	95% CI	Estimated annual costs³
Maternal indirect costs	96	2813	3950	215	11,241	2221; 3394	11,252
Quit work	24	1466	3796	0	11,241	916; 2016	5864
Reduction of working hours	49	1109	2136	0	8774	808; 1438	4436
Days off due to TSC	41	238	628	0	4300	153; 332	952
Paternal indirect costs	48	372	1345	0	11,241	193; 586	1488
Quit work	2	122	1169	0	11,241	0; 306	488
Reduction of working hours	7	86	531	0	5621	22; 169	344
Days off due to TSC	41	163	452	0	3440	101; 233	652
Total parents	111	3184	4326	645	22,482	2533; 3811	12,736

95% CI = 95% Confidence interval using the bootstrap bias corrected and accelerated method
¹Parents of working age
²Standard deviation
³Estimation based on the mean costs in three months multiplied by four

ISSN: 1750-1172