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Table 4 Patients with multiple samples analysed

From: Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations

Sequenced samples

Common code

Pathology

Mutation

VAF (%)

Average VAF (%)

SD VAF (%)

VA-10

VA-10

LM

E545G

10.01

8.28

2.45

VA-47.pKPT

E545G

6.55

VA-1124.pKPT

VA-1124

CLOVES

E453K

13.51

8.64

6.89

VA-1133.pKPT

E453K

3.76

VA-1126.pKPT

VA-1126

CLOVES

VA-1126.pRASO2

VA-1126-T.pCMAVM

VA-1158-T.pKPT

VA-1158-T

CLOVES

E545K

12.16

8.66

4.17

VA-1158-T-1.pTVPP

E545K

9.77

VA-1158-T-2.pTVPP

E545K

4.05

VA-230.pKPT

VA-230

LM

H1047L

2.52

2.50

0.04

VA-298.pKPT

H1047L

2.47

VA-24.pKPT

VA-24

LM

VA-240.pKPT

VA-986.pKPT

VA-312.pKPT

VA-312

LM

E110delE

1.06

1.90

0.82

VA-339.pKPT

E110delE

1.95

VA-403.pKPT

E110delE

2.70

VA-364.pKPT

VA-364

LM

E542K

1.11

2.74

2.30

VA-421.pKPT

E542K

4.36

VA-50.pKPT

VA-50

LM

E542K

4.95

6.56

2.28

VA-790.pKPT

E542K

8.17

VA-528.pKPT

VA-528

LM

E545K

4.3

4.93

2.39

VA-714.pKPT

E545K

6.24

VA-830.pKPT

E545K

7.32

VA-913.pKPT

E545K

1.87

VA-711.pKPT

VA-711

LM

H1047R

5.66

8.33

3.77

VA-829.pKPT

H1047R

10.99

VA-756.pKPT

VA-756

LVM

E542K

8.25

7.07

1.67

VA-979.pKPT

E542K

5.89

VA-1037.pKPT

VA-886

LM

Q546R

2.16

3.06

1.27

VA-886.pKPT

Q546R

3.96

VA-868-T.pRASO2

VA-868

LM

E542K

2.11

3.78

2.36

VA-1245.pKPT

E542K

5.45

VA-869-T.pRASO2

VA-869

LM

E545K

4.0

2.87

1.61

VA-1243.pKPT

E545K

1.73

VA-1041.pKPT

VA-916

LM

H1047R

3.86

3.10

1.08

VA-916.pKPT

H1047R

2.33

  1. VAF, variant allele frequency; SD, standard deviation; mean of averages = 5.17%; mean of SDs = 2.36%