Table 1 Patients cohort and PIK3CA mutations per pathology

Cohort

105

3

1

7

4

14

7

2

143

Mutation

78

3

–

6

4

12

5

–

108

No mutation

19

–

1

1

–

2

2

2

27

Inconclusive

8

–

–

–

–

–

–

–

8

% with a mutation

74.3%

100%

0%

85.7%

100%

85.7%

71.4%

0%

75.5%

VAF median

3.71

4.59

–

7.34

8.12

12.90

11.09

–

4.05

Standard deviation

4.49

2.52

–

6.53

6.27

7.30

5.65

–

4.85

VAF range

0.54–11.34

3.43–8.25

–

4.71–22.19

1.15–13.17

2.00–25.33

1.00–13.00

–

0.54–25.33

Hotspot mutations

74

3

0

6

3

5

1

0

92

Non-hotspot mutations

4

0

0

0

1

7

4

0

16

ABD

F83S

1

1

 ABD

P104L

1

1

E110del

1

1

2

G118D

1

1

Y165C

1

1

C2

C420R

1

1

 C2

E453K

1

1

E494K

1

1

Helical

E542K

26

3

1

1

31

 Helical

E545K

27

3

3

1

34

 Helical

E545G

1

1

 Helical

Q546K

2

2

 Helical

Q546R

1

1

E76K

1

1

Kinase

G914R

1

1

 Kinase

Y1021H

1

1

 Kinase

T1025A

1

1

 Kinase

H1047R

17

3

3

23

 Kinase

H1047L

3

3