Fig. 4

VAF distributions. a Highly significant difference in VAF between common and combined LMs (LM, LVM,CLM) versus syndromes (PROS), and b versus CLOVES. No statistically significant difference between common and combined LMs versus unclassified PROS or KTS, nor between LVM or CLVM versus syndromes. c Significant difference between common LM versus syndromes (PROS), and d versus CLOVES. There was no statistically significant difference between any other entities (Additional file 1: Table S1). e, f, no statistically significant difference between VAF and hostpot/non-hotspot or each of the hotspots individually (Additional file 1: Table S1). g–i no statistically significant differences between VAF and LM localization (g) (Additional file 1: Table S1), size (h) (Additional file 1: Table S1) or cystic structure (i) (Additional file 1: Table S1). ***p value < 0.001