Symptom concepts | Treated group (n = 20) | Treatment-naïve group (n = 17) | ||||
---|---|---|---|---|---|---|
Frequency, % | Severity rating, mean (n) | Bothersome rating, mean (n) | Frequency, % | Severity rating, mean (n) | Bothersome rating, mean (n) | |
Neuropathic pain symptoms | 95.0 | 82.4 | ||||
Burning pain | 80.0 | 7.9 (9) | 5.0 (7) | 47.1 | 7.3 (6) | 6.6 (5) |
Crisis pain | 60.0 | 8.7 (3) | 5.8 (5) | 29.4 | 7.5 (2) | 7.5 (2) |
Neuropathic pain | 10.0 | 10.0 (1) | 6.0 (1) | 0.0 | – | – |
Numbness | 70.0 | 5.8 (1) | 5.8 (5) | 23.5 | 7.3 (3) | 8.0 (3) |
General pain | 75.0 | 8.0 (7) | 5.8 (4) | 41.2 | 9.5 (2) | 10.0 (2) |
Tingling | 45.0 | 5.3 (4) | 3.0 (3) | 52.9 | 6.3 (7) | 5.3 (7) |
Other pain symptoms | 90.0 | 64.7 | ||||
Headache/migraine | 55.0 | 6.8 (6) | 5.7 (6) | 52.9 | 5.3 (6) | 5.0 (6) |
Localized pain | 40.0 | 8.3 (3) | 6.5 (2) | 23.5 | 6.8 (5) | 7.0 (4) |
Whole body pain | 45.0 | 5.9 (7) | 7.3 (4) | 35.3 | 9.5 (2) | 9.0 (2) |
Digestive/gastrointestinal symptoms | 80.0 | 58.8 | ||||
Constipation | 15.0 | 6.5 (2) | 8.7 (3) | 23.5 | 7.0 (3) | 7.0 (3) |
Cramping | 20.0 | 7.8 (4) | 5.8 (4) | 11.8 | 8.0 (1) | – |
Diarrhea | 75.0 | 6.8 (12) | 5.2 (9) | 35.3 | 6.8 (6) | 6.5 (4) |
Digestion and heartburn | 25.0 | – | – | 11.8 | – | – |
Gas and bloating | 15.0 | 10.0 (1) | 10.0 (1) | 23.5 | 7.0 (1) | 6.0 (1) |
Nausea | 15.0 | – | – | 11.8 | 8.0 (1) | 8.0 (1) |
Stomach pain | 30.0 | 10.0 (1) | 10.0 (1) | 35.3 | 7.5 (4) | 9.8 (4) |
Upset stomach | 35.0 | 6.5 (2) | 5.3 (3) | 35.3 | – | – |
Urgency | 35.0 | 8.3 (6) | 6.8 (4) | 11.8 | 7.0 (1) | 2.5 (2) |
Vomiting | 10.0 | – | 5.0 (1) | 5.9 | 2.0 (1) | 10.0 (1) |
Temperature intolerance and change | 95.0 | 88.2 | ||||
Cold intolerance | 55.0 | 5.6 (7) | 4.4 (5) | 58.8 | 7.9 (7) | 6.1 (8) |
General fever | 45.0 | 6.5 (2) | 4.7 (3) | 11.8 | – | – |
Excessive sweating | 0 | 8.0 (1) | 10.0 (1) | 17.6 | 5.6 (5) | 5.0 (2) |
Heat intolerance | 85.0 | 7.4 (14) | 6.7 (14) | 47.1 | 7.4 (10) | 6.8 (5) |
Lack of sweating | 65.0 | 6.6 (11) | 3.2 (11) | 52.9 | 5.2 (5) | 2.2 (9) |
Localized fever | 5.0 | 10.0 (1) | 7.0 (1) | 0.0 | – | – |
Temperature insensitivity | 5.0 | 10.0 (1) | 2.0 (1) | 0.0 | – | 7.0 (1) |
Edema | 55.0 | 41.2 | ||||
Swelling | 55.0 | 6.4 (10) | 6.4 (11) | 41.2 | 4.8 (5) | 4.2 (5) |
Other edema | 5.0 | – | 10.0 (1) | 0.0 | – | – |
Energy difficulties | 95.0 | 94.1 | ||||
Fatigue | 70.0 | 7.7 (9) | 9.0 (9) | 47.1 | 6.8 (4) | 7.4 (5) |
Low stamina | 15.0 | 6.0 (1) | 6.0 (1) | 11.8 | – | – |
Low or no energy | 40.0 | 6.0 (1) | 5.5 (2) | 41.2 | 6.0 (1) | 8.0 (2) |
Physical weakness | 30.0 | – | – | 0.0 | – | – |
Tiredness | 90.0 | 6.9 (11) | 7.2 (10) | 76.5 | 7.4 (10) | 7.5 (11) |
Hearing and vision problems | 95.0 | 70.6 | ||||
Earache | 5.0 | 6.0 (2) | 9.5 (2) | 0.0 | – | – |
Hearing loss | 75.0 | 7.1 (8) | 6.3 (8) | 17.6 | 4.0 (1) | – |
Tinnitus | 50.0 | 3.8 (9) | 3.9 (9) | 47.1 | 5.8 (8) | 7.5 (11) |
Dry eyes | 10.0 | 8.0 (1) | 10.0 (1) | 0.0 | – | – |
Sight impairment | 50.0 | 6.6 (5) | 6.2 (5) | 17.6 | 5.5 (2) | 5.3 (3) |
Corneal whorling | 30.0 | 0.0 (1) | – | 11.8 | – | 0.0 (1) |
Other eye problems | 5.0 | – | – | 11.8 | – | – |
Skin problems | 80.0 | 23.5 | ||||
Angiokeratomas | 20.0 | 2.0 (1) | 2.0 (1) | 23.5 | – | – |
Rash | 45.0 | 4.9 (10) | 2.3 (11) | 0.0 | 3.3 (3) | 2.0 (3) |
Other skin problems | 30.0 | – | – | 0.0 | 6.0 (1) | 5.0 (1) |
Cardiac problems | 70.0 | 52.9 | ||||
General heart problems | 20.0 | – | 1.0 (1) | 41.2 | 5.0 (2) | 4.5 (4) |
Heart damage | 35.0 | 5.0 (5) | 7.2 (6) | 11.8 | 7.5 (2) | 4.0 (4) |
Heart palpitations/arrhythmia | 45.0 | 6.3 (5) | 6.0 (6) | 5.9 | 4.8 (4) | 2.5 (4) |
Respiratory problems | 50.0 | – | – | 64.7 | ||
Breathing difficulty | 35.0 | 9.0 (2) | 9.7 (3) | 41.2 | 5.0 (1) | 8.0 (1) |
Coughing | 25.0 | 9.0 (1) | 7.0 (1) | 41.2 | 6.0 (1) | 5.0 (1) |
Other respiratory problems | 95.0 | 9.0 (1) | 9.0 (1) | 17.6 | – | – |
Additional symptoms | 15.0 | 88.2 | ||||
Blood pressure | 15.0 | 8.0 (1) | 5.0 (1) | 5.9 | – | – |
Cerebrovascular symptoms | 20.0 | – | – | 5.9 | – | – |
Patient reports of cerebrovascular events | 30.0 | 8.3 (3) | 7.3 (3) | 5.9 | 10.0 (1) | 10.0 (1) |
Dizziness or lightheadedness | 50.0 | 8.0 (3) | 5.7 (3) | 29.4 | 8.3 (3) | 8.7 (3) |
Feeling ill | 40.0 | – | – | 17.6 | – | – |
Patient-expressed kidney signs and symptoms | 30.0 | 3.3 (4) | 5.4 (7) | 41.2 | 8.0 (1) | 4.1 (8) |
Patient reports of kidney-related clinical findings | 40.0 | – | – | 47.1 | – | – |
Musculoskeletal problems | 40.0 | 6.3 (3) | 5.3 (3) | 11.8 | 10.0 (1) | 7.0 (2) |
Speaking difficulties | 20.0 | – | – | 0.0 | – | – |
Urinary problems | 35.0 | 2.0 (2) | 5.5(2) | 11.8 | 9.3 (3) | 6.3 (3) |
Other symptoms | 25.0 | – | – | 5.9 | – | – |