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Table 8 Clinical information and liver function test results of normal pregnant women and patients in every subgroup of ICP

From: Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy

Subjects

Normal pregnant (n = 50)

ICP1 (n = 51)

ICP2 (n = 27)

ICP3 (n = 22)

ICP4 (n = 44)

H/χ2

P

Age (year)

28 (26, 32)

30 (27, 31)

29 (23, 33)

28 (27, 31)

29 (27, 33)

1.441

0.837

Gravidity

2 (1, 3)

2 (1, 3)

2 (1, 3)

1 (1, 2)

2 (1, 2)

8.069

0.089

Delivery pregnancy week

39 (38, 40)

37 (35, 39)a

37 (36, 38)a

38 (37, 39.0)a

37 (36, 39)a

36.587

0.000

Previous history of ICP (n, %)

0 (0%)

2 (3.9%)

5 (18.5%)a

2 (9.1%)

4 (9.1%)

10.855

0.028

Pregnancy outcome (n, %)

       

Cesarean section

4 (8%)

42 (82.4%)a

18 (66.7%)a,b

8 (36.7%)b

18 (40.9%)a,b

53.982

0.000

Premature (< 37w)

0 (0%)

39 (76.5%)a

2 (7.4%)a,b

2 (9.1%)a,b

5 (11.4%)a,b

30.81

0.000

Meconium-stained amniotic fluid

1 (2%)

19 (37.3%)a

4 (14.8%)a,b

3 (13.6%)a,b

8 (18.2%)a,b

27.324

0.000

Neonatal ICU hospitalization rate

1 (2%)

17 (33.3%)a

5 (18.5%)a

0 (0%)

5 (11.4%)

25.422

0.000

1 min Apgar scores ≤ 7

1 (2%)

12 (23.5%)a

2 (7.4%)

2 (9.1%)

3 (6.8%)b

21.185

0.000

Newborn weight (g)

3305 (2980, 3592)

3180 (2720, 3370)a

2900 (2720, 3360)a

3185 (2837, 3320)

2960 (2565, 3870)

10.774

0.029

Postpartum hemorrhage (ml)

225 (200, 300)

200 (200, 300)

300 (200, 300)

200 (200, 285)

300 (200, 300)a

11.077

0.026

Liver function test results

       

TBA (umol/L)

3.3 (2.4, 4.5)

32.0 (16.5, 48.1)a

18.8 (12.0, 28.8)a,b

19.9 (16.9, 29.4)a

6.2 (4.4, 7.4)a,b,c

149.387

0.000

TBIL (umol/L)

11.0 (8.8, 12.9)

18.0 (13.4, 26.6)a

8.4 (5.4, 12.1)a,b

6.5 (4.5, 10.1)a,b

8.2 (6.3, 10.4)a,b

94.044

0.000

DBIL (umol/L)

3.4 (2.6, 4.8)

12.6 (8.3, 16.8)a

3.7 (2.2, 5.1)a,b

3 (2.4, 3.6)a,b

3.8 (3.0, 4.5)a,b,d

123.664

0.000

ALT (U/L)

19.0 (17.0, 25.3)

216.0 (106.0, 336.0)a

176.0 (95.0, 309.0)a

10.0 (7.8, 13.5)a,b

104.5 (70.0, 174.8)a,b,d

142.102

0.000

AST (U/L)

18.0 (15.8, 22.0)

146.0 (73.0, 205.0)a

116.8 (60.0, 232.0)a

15.5 (12.0, 18.0)a,b

51.5 (35.3, 76.5)a,b,d

141.737

0.000

  1. The data in the table is expressed by M (Q1, Q3)
  2. aP < 0.05 compared with normal pregnant women
  3. bCompared with ICP1 group, P < 0.05
  4. cCompared with the ICP2 group, P < 0.05
  5. dComparing the ICP3 group with the ICP4 group, P < 0.05