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Table 3 Average annual costs per patient by country (€2019) at the 12-month visit

From: Economic burden and health-related quality of life in tenosynovial giant-cell tumour patients in Europe: an observational disease registry

  AUT (n = 9) GER (n = 12) SP (n = 13) FRA (n = 4) ITA (n = 38) NLD (n = 61) ALL (n = 137)
Visits to GPs, mean (sd) 31.43 (94.30) 18.17 (38.63) 0.00 (0.00) 0.00 (0.00) 22.37 (52.79) 10.71* (66.57) 14.63* (58.54)
Visits to specialists, mean (sd) 48.36* (71.42) 227.30 (434.95) 69.99 (153.85) 0.00 (0.00) 152.19* (249.74) 340.78 (340.17) 223.68* (314.72)
Physiotherapy sessions, mean (sd) 271.99 (364.05) 294.60 (716.04) 0.00 (0.00) 17.49 (34.98) 77.24 (233.56) 242.28 (478.41) 173.48 (418.74)
Rehabilitation sessions (days), mean (sd) 0.00 (0.00) 84.84 (293.89) 0.00 (0.00) 0.00 (0.00) 78.80 (238.28) 0.00* (0.00) 29.29* (154.72)
Total medical visit costs, mean (sd) 351.78 (456.74) 624.91 (1,118.68) 69.99 (153.85) 17.49 (34.98) 330.61* (533.57) 593.77 (595.08) 441.08* (620.57)
Hospital admission costs due to surgery, mean (sd) 3200* (5873.22) 1840.72* (4873.27) 0 (0) 0 (0) 1224.78* (4299.81) 6494.20* (2346.02) 3612.02 (3201.29)
Hospital admission costs for other reasons, mean (sd) 890.31 (1568.10) 9185.94* (969.55) 0 (0) 0 (0) - 48.87* (127.53) 874.48* (1671.24)
MRI, mean (sd) 433.36 (375.30) 131.21 (167.84) 266.64 (338.17) 0.00 (0.00) 99.68 (74.38) 164.20* (185.79) 166.02 (212.68)
Direct healthcare costs, mean (sd) 4875.46 (7902.45) 11,782.78 (28,794.26) 336.64 (312.40) 17.49 (34.98) 1655.20 (4320.65) 7298.48* (7053.83) 5093.60 (10,494.22)
Annual informal caregiving, mean (sd) 0 (0) 0.00 (0.00) 0.00 (0.00) 0.00 (0.00) 6.92* (23.94) 0.00 (0.00) 1.92 (12.87)
Annual productivity loss caused by TGCT, mean (sd) 405.80 (1217.40) 28.06* (57.14) 0.00 (0.00) 0.00 (0.00) 81.69* (255.77) 29.53* (128.92) 64.92* (348.64)
Total costs caused by TGCT, mean (sd) 5281.26 (7819.10) 11,810.84 (28,810.61) 336.64 (312.40) 17.49 (34.98) 1743.81 (4362.88) 7328.01* (7063.49) 5160.44 (10,497.92)
  1. AUT = Austria; GER = Germany; SP = Spain; FRA = France; ITA = Italy; NLD = The Netherlands; LOS: Length Of Stay; MRI: Magnetic Resonance Imaging; TGCT: Tenosynovial Giant-Cell Tumour. Note: ‘Total medical visit cost’ includes the economic valuation of visits to GPs, visits to specialists, physiotherapy sessions and rehabilitation sessions.
  2. *Mean cost was statistically different (p-value < 0.05) from baseline moment according to the two-sample t-test assuming unequal variances