Fig. 3

Pathomechanism of the manifestations of Marfan syndrome and connection points of the potential predictors. Our current understanding of the pathomechanism of aortic complications in Marfan syndrome is demonstrated in this figure, also highlighting those alterations that were previously described as possible predictors for severe aortic complications. The red figures illustrate the biomarkers discussed in this review, while the blue ones demonstrate the other relevant aspects in the pathomechanism of the manifestations of Marfan syndrome. The red arrows show the final causal steps in the formation of aortic complications, and the blue ones indicate the connections between the processes taking part in the pathomechanism