Table 3 Findings of MPS I newborn screening in six different states
From: Epidemiology of mucopolysaccharidoses (MPS) in United States: challenges and opportunities
States | Missouri | Illinois | Washington | North Carolina | Kentucky | New York |
|---|---|---|---|---|---|---|
Screened positive | 133 | 151 | 9 | 54 | 57 | 13 |
True positive | 2 | 1 | 3 | 1 | 1 | 0 |
Carriers | 8 | 5 | 1 | 2 | NA | 4 |
Pseudodeficiency | 71 | 30 | 0 | 13 | NA | 8 |
False-positive results | 45 | 87 | 5 | NA | NA | 0 |
Undetermined disease status | 2 | 4 | NA | 3 | NA | 1 |
Unresolved/status pending | 5 | 24 | NA | NA | NA | 0 |
Lost/refused follow-up | 0 | 0 | NA | 1 | NA | 0 |
Total number of screened newborns | 308,000 | 219,793 | 106,526 | 62,734 | 55,161 | 35,816 |
Incidence per 100,000 | 0.65 | 0.45 | 2.81 | 1.59 | 1.81 | 0 |