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Table 3 Distribution of weight z-scores of treated and untreated MPS II patients at baseline, year 1, and year 2 of follow up as classified in to age groups

From: A review of the clinical outcomes in idursulfase-treated and untreated Filipino patients with mucopolysaccharidosis type II: data from the local lysosomal storage disease registry

 

All (n = 11)

Treated (n = 2)

Untreated (n = 9)

Group 1

Baseline

 Underweight (z < − 2)

%

0

0

0

 Normal (z < − 1 to + 2)

%

9

81.9%

2

100%

7

77.78%

 Overweight (z >  + 2)

%

2

18.1%

0

2

22.22%

Year 1

 Underweight (z < − 2)

%

1

9%

0

1

11.11%

 Normal (z < − 1 to + 2)

%

8

72.72

2

100%

6

66.67%

 Overweight (z >  + 2)

%

2

18.18

0

2

22.22

Year 2

 Underweight (z < − 2)

%

1

9%

0

1

11.11%

 Normal (z < − 1 to + 2)

%

9

81.9%

2

100%

7

77.78%

 Overweight (z >  + 2)

%

1

9%

0

1

11.11%

Group 2

Baseline

(n = 16; Treated = 1; Untreated = 15)

 Underweight (z < − 2)

%

3

18.75%

1

2

13.33%

 Normal (z < − 1 to + 2)

%

13

81.25%

0

13

86.67%

 Overweight (z >  + 2)

%

0

0

0

Year 1

(n = 13; Treated = 1; Untreated = 12)

 Underweight (z < − 2)

%

4

30.77%

1

3

25%

 Normal (z < − 1 to + 2)

%

9

69.23%

0

9

75%

 Overweight (z >  + 2)

%

0

0

0

Year 2

(n = 11; Treated = 0; Untreated = 11)

 Underweight (z < − 2)

%

5

45.45%

NA

5

45.45%

 Normal (z < − 1 to + 2)

%

6

54.54%

NA

6

54.54%

 Overweight (z >  + 2)

%

0

NA

0

Group 3

Baseline

(n = 13; Treated = 5; Untreated = 8)

 Underweight (z < − 2)

%

10

76.9%

4

80%

6

75%

 Normal (z < − 1 to + 2)

%

3

23.2%

1

20%

2

25%

 Overweight (z >  + 2)

%

0

0

0

Year 1

(n = 12; Treated = 5; Untreated = 7)

 Underweight (z < − 2)

%

11

91.67%

4

80%

7

100%

 Normal (z < − 1 to + 2)

%

1

12.5%

1

20%

0

 Overweight (z >  + 2)

%

0

0

0

Year 2

(n = 8; Treated = 4; Untreated = 4)

 Underweight (z < − 2)

%

7

87.5%

3

75%

4

100%

 Normal (z < − 1 to + 2)

%

1

12.5%

1

25%

0

 Overweight (z >  + 2)

%

0

0

0

  1. Group 1: aged < 6 years at start of ERT or at time of diagnosis; Group 2: aged 6–10 years at start of ERT or at time of diagnosis; Group 3: aged > 10 years at start of ERT or at time of diagnosis