Birth prevalence of phenylalanine hydroxylase deficiency: a systematic literature review and meta-analysis

Table 5 Comparison of birth prevalence estimates among recent literature reviews

Region	Birth prevalence estimate per 10,000 (95% CI)
Region	Hillert et al. [46]	Shoraka et al. [47]	This study^b
Europe^a	NR	0.81 (0.65–0.97)	1.14 (0.89–1.41)
Middle East/North Africa	NR	NR	1.18 (0.64–1.87)
Eastern Mediterranean	NR	0.98 (0.62–1.35)	NR
Pan America	NR	0.53 (0.46–0.61)	NR
Latin America	NR	NR	0.98 (0.29–2.03)
North America	NR	NR	0.81 (0.58–1.07)
Southeast Asia	NR	0.03 (0.02–0.05)	0.03 (0.02–0.05)
West Pacific	NR	0.29 (0.09–0.50)	0.68 (0.43–0.98)
Global (non-regionally weighted)	NR	0.60 (0.51–0.69)	0.96 (0.75–1.19)
Global (regionally weighted)	0.42 (NR)	NR	0.64 (0.53–0.75)^c

CI = confidence interval; NR = not reported
^aShoraka et al. incorrectly classified one included publication as European when it was in fact a North American study
^bTable 4 presents the birth prevalence estimates from this analysis in further detail
^cGlobal prevalence was calculated by weighting each region by its relative contribution to the total population

ISSN: 1750-1172