Skip to main content

Table 5 Comparison of birth prevalence estimates among recent literature reviews

From: Birth prevalence of phenylalanine hydroxylase deficiency: a systematic literature review and meta-analysis

Region Birth prevalence estimate per 10,000 (95% CI)
Hillert et al. [46] Shoraka et al. [47] This studyb
Europea NR 0.81 (0.65–0.97) 1.14 (0.89–1.41)
Middle East/North Africa NR NR 1.18 (0.64–1.87)
Eastern Mediterranean NR 0.98 (0.62–1.35) NR
Pan America NR 0.53 (0.46–0.61) NR
Latin America NR NR 0.98 (0.29–2.03)
North America NR NR 0.81 (0.58–1.07)
Southeast Asia NR 0.03 (0.02–0.05) 0.03 (0.02–0.05)
West Pacific NR 0.29 (0.09–0.50) 0.68 (0.43–0.98)
Global (non-regionally weighted) NR 0.60 (0.51–0.69) 0.96 (0.75–1.19)
Global (regionally weighted) 0.42 (NR) NR 0.64 (0.53–0.75)c
  1. CI = confidence interval; NR = not reported
  2. aShoraka et al. incorrectly classified one included publication as European when it was in fact a North American study
  3. bTable 4 presents the birth prevalence estimates from this analysis in further detail
  4. cGlobal prevalence was calculated by weighting each region by its relative contribution to the total population