Skip to main content

Table 1 HLA alleles associated with BP identified in this study

From: Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Gene

Allele

Study

P-value

95% CI [lower, upper]

P-value (Hommel adjusted)

OR

OR [lower, upper]

A

A*03:01

Discovery

0.034710658

[0.0208, 0.5591]

0.99908782

1.342686047

[1.0279, 1.7538]

Replication

0.58697531

[− 2.3684, 2.4882]

Meta-analysis

0.030601855

[0.0276, 0.5618]

B

B*08:01

Discovery

0.02405483

[− 1.0689, − 0.0751]

0.354370169

0.571262096

[0.3987, 0.8184]

Replication

0.122675915

[− 1.6824, 0.1457]

Meta-analysis

0.002271604

[− 0.9194, − 0.2004]

B*37:01

Discovery

0.014767834

[− 2.1156, − 0.2300]

0.99908782

0.309496161

[0.1206, 0.7946]

Replication

 

[NA, NA]

Meta-analysis

0.014767834

[− 2.1156, − 0.2300]

B*38:01

Discovery

0.034632674

[0.0562, 1.4982]

0.99908782

2.265753431

[1.1271, 4.5546]

Replication

0.31618692

[− 1.8167, 4.6785]

Meta-analysis

0.021680056

[0.1197, 1.5161]

C

C*04:01

Discovery

0.001280217

[0.2229, 0.9162]

0.421598674

1.637652525

[1.1862, 2.2609]

Replication

0.996052508

[− 0.9515, 0.8322]

Meta-analysis

0.002719991

[0.1708, 0.8158]

C*06:02

Discovery

0.008418861

[− 0.7650, − 0.1124]

0.99908782

0.681311521

[0.5036, 0.9218]

Replication

0.900089924

[− 0.9435, 0.6911]

Meta-analysis

0.012845693

[− 0.6860, − 0.0814]

DQA1

DQA1*02:01

Discovery

0.000236558

[− 1.0487, − 0.3194]

0.99908782

0.585901665

[0.3874, 0.8860]

Replication

0.821096838

[− 1.0133, 0.6346]

Meta-analysis

0.011292202

[− 0.9482, − 0.1210]

DQA1*05:01

Discovery

0.01391165

[− 1.8228, − 0.2060]

0.99908782

0.454746049

[0.2362, 0.8757]

Replication

0.710972174

[− 1.1973, 0.6923]

Meta-analysis

0.01842072

[− 1.4433, − 0.1328]

DQA1*05:05

Discovery

1.23189E-08

[0.5081, 1.0413]

8.97827E07

2.04569062

[1.6082, 2.6022]

Replication

0.109203061

[− 0.1211, 1.0059]

Meta-analysis

5.54214E-09

[0.4751, 0.9564]

DQB1

DQB1*02:01

Discovery

0.01391165

[− 1.8228, − 0.2060]

0.109465545

0.401052978

[0.2366, 0.6797]

Replication

0.167679623

[− 1.9823, 0.2065]

Meta-analysis

0.000688463

[− 1.4413, − 0.3861]

DQB1*02:02

Discovery

0.00278635

[− 1.0331, − 0.2150]

0.630186648

0.581980108

[0.4020, 0.8426]

Replication

0.70501071

[− 1.1817, 0.6072]

Meta-analysis

0.004145965

[− 0.9114, − 0.1712]

DQB1*03:01

Discovery

1.10574E−05

[0.4521, 1.1798]

0.99908782

1.835883195

[1.0057, 3.3513]

Replication

0.889954019

[− 0.4514, 0.5064]

Meta-analysis

0.047871422

[0.0057, 1.2094]

DRB1

DRB1*03:01

Discovery

0.00383576

[− 1.5352, − 0.2947]

0.99908782

0.233278746

[0.2608, 0.9996]

Replication

0.96806271

[− 0.8528, 0.8063]

Meta-analysis

0.049872143

[− 1.3439, − 0.0004]

DQB1*06:01

Discovery

0.032188411

[− 2.7873, − 0.1237]

0.99908782

0.510607993

[0.0616, 0.8836]

Replication

 

[NA, NA]

Meta-analysis

0.032188411

[− 2.7873, − 0.1237]

DRB1*07:01

Discovery

0.000236558

[− 1.0487, − 0.3194]

0.01463864

0.51542337

[0.3698, 0.7183]

Replication

0.170712241

[− 1.4540, 0.1740]

Meta-analysis

9.09232E-05

[− 0.9947, − 0.3308]

DRB1*11:01

Discovery

0.011897502

[0.1177, 0.9489]

0.069015473

1.627822652

[1.2409, 2.1354]

Replication

0.176829458

[− 0.2289, 1.1130]

Meta-analysis

0.00043406

[0.2158, 0.7587]

DRB1*12:01

Discovery

0.00440014

[0.4163, 2.2540]

0.99908782

3.18164846

[1.3614, 7.4358]

Replication

0.914702144

[− 2.8669, 2.0659]

Meta-analysis

0.007535421

[0.3085, 2.0063]

DRB1*15:02

Discovery

0.032188411

[− 2.7873, − 0.1237]

0.99908782

0.233278746

[0.0616, 0.8836]

Replication

 

[NA, NA]

Meta-analysis

0.032188411

[− 2.7873, − 0.1237]

  1. Numbers in bald, statistically significant value in the meta-analysis
  2. OR odds ratio, CI confidence interval