Gene | Allele | Study | P-value | 95% CI [lower, upper] | P-value (Hommel adjusted) | OR | OR [lower, upper] |
---|---|---|---|---|---|---|---|
A | A*03:01 | Discovery | 0.034710658 | [0.0208, 0.5591] | 0.99908782 | 1.342686047 | [1.0279, 1.7538] |
Replication | 0.58697531 | [− 2.3684, 2.4882] | |||||
Meta-analysis | 0.030601855 | [0.0276, 0.5618] | |||||
B | B*08:01 | Discovery | 0.02405483 | [− 1.0689, − 0.0751] | 0.354370169 | 0.571262096 | [0.3987, 0.8184] |
Replication | 0.122675915 | [− 1.6824, 0.1457] | |||||
Meta-analysis | 0.002271604 | [− 0.9194, − 0.2004] | |||||
B*37:01 | Discovery | 0.014767834 | [− 2.1156, − 0.2300] | 0.99908782 | 0.309496161 | [0.1206, 0.7946] | |
Replication | [NA, NA] | ||||||
Meta-analysis | 0.014767834 | [− 2.1156, − 0.2300] | |||||
B*38:01 | Discovery | 0.034632674 | [0.0562, 1.4982] | 0.99908782 | 2.265753431 | [1.1271, 4.5546] | |
Replication | 0.31618692 | [− 1.8167, 4.6785] | |||||
Meta-analysis | 0.021680056 | [0.1197, 1.5161] | |||||
C | C*04:01 | Discovery | 0.001280217 | [0.2229, 0.9162] | 0.421598674 | 1.637652525 | [1.1862, 2.2609] |
Replication | 0.996052508 | [− 0.9515, 0.8322] | |||||
Meta-analysis | 0.002719991 | [0.1708, 0.8158] | |||||
C*06:02 | Discovery | 0.008418861 | [− 0.7650, − 0.1124] | 0.99908782 | 0.681311521 | [0.5036, 0.9218] | |
Replication | 0.900089924 | [− 0.9435, 0.6911] | |||||
Meta-analysis | 0.012845693 | [− 0.6860, − 0.0814] | |||||
DQA1 | DQA1*02:01 | Discovery | 0.000236558 | [− 1.0487, − 0.3194] | 0.99908782 | 0.585901665 | [0.3874, 0.8860] |
Replication | 0.821096838 | [− 1.0133, 0.6346] | |||||
Meta-analysis | 0.011292202 | [− 0.9482, − 0.1210] | |||||
DQA1*05:01 | Discovery | 0.01391165 | [− 1.8228, − 0.2060] | 0.99908782 | 0.454746049 | [0.2362, 0.8757] | |
Replication | 0.710972174 | [− 1.1973, 0.6923] | |||||
Meta-analysis | 0.01842072 | [− 1.4433, − 0.1328] | |||||
DQA1*05:05 | Discovery | 1.23189E-08 | [0.5081, 1.0413] | 8.97827E−07 | 2.04569062 | [1.6082, 2.6022] | |
Replication | 0.109203061 | [− 0.1211, 1.0059] | |||||
Meta-analysis | 5.54214E-09 | [0.4751, 0.9564] | |||||
DQB1 | DQB1*02:01 | Discovery | 0.01391165 | [− 1.8228, − 0.2060] | 0.109465545 | 0.401052978 | [0.2366, 0.6797] |
Replication | 0.167679623 | [− 1.9823, 0.2065] | |||||
Meta-analysis | 0.000688463 | [− 1.4413, − 0.3861] | |||||
DQB1*02:02 | Discovery | 0.00278635 | [− 1.0331, − 0.2150] | 0.630186648 | 0.581980108 | [0.4020, 0.8426] | |
Replication | 0.70501071 | [− 1.1817, 0.6072] | |||||
Meta-analysis | 0.004145965 | [− 0.9114, − 0.1712] | |||||
DQB1*03:01 | Discovery | 1.10574E−05 | [0.4521, 1.1798] | 0.99908782 | 1.835883195 | [1.0057, 3.3513] | |
Replication | 0.889954019 | [− 0.4514, 0.5064] | |||||
Meta-analysis | 0.047871422 | [0.0057, 1.2094] | |||||
DRB1 | DRB1*03:01 | Discovery | 0.00383576 | [− 1.5352, − 0.2947] | 0.99908782 | 0.233278746 | [0.2608, 0.9996] |
Replication | 0.96806271 | [− 0.8528, 0.8063] | |||||
Meta-analysis | 0.049872143 | [− 1.3439, − 0.0004] | |||||
DQB1*06:01 | Discovery | 0.032188411 | [− 2.7873, − 0.1237] | 0.99908782 | 0.510607993 | [0.0616, 0.8836] | |
Replication | [NA, NA] | ||||||
Meta-analysis | 0.032188411 | [− 2.7873, − 0.1237] | |||||
DRB1*07:01 | Discovery | 0.000236558 | [− 1.0487, − 0.3194] | 0.01463864 | 0.51542337 | [0.3698, 0.7183] | |
Replication | 0.170712241 | [− 1.4540, 0.1740] | |||||
Meta-analysis | 9.09232E-05 | [− 0.9947, − 0.3308] | |||||
DRB1*11:01 | Discovery | 0.011897502 | [0.1177, 0.9489] | 0.069015473 | 1.627822652 | [1.2409, 2.1354] | |
Replication | 0.176829458 | [− 0.2289, 1.1130] | |||||
Meta-analysis | 0.00043406 | [0.2158, 0.7587] | |||||
DRB1*12:01 | Discovery | 0.00440014 | [0.4163, 2.2540] | 0.99908782 | 3.18164846 | [1.3614, 7.4358] | |
Replication | 0.914702144 | [− 2.8669, 2.0659] | |||||
Meta-analysis | 0.007535421 | [0.3085, 2.0063] | |||||
DRB1*15:02 | Discovery | 0.032188411 | [− 2.7873, − 0.1237] | 0.99908782 | 0.233278746 | [0.0616, 0.8836] | |
Replication | [NA, NA] | ||||||
Meta-analysis | 0.032188411 | [− 2.7873, − 0.1237] |