Table 1 Demographic data of studies comparing early-onset with late-onset NTMG after thymectomy
Author/year/country | Study design | Study period | Follow-up (y) mean/range | Age (y) (cutoff/range) | Early-onset (events/all) | Late-onset (events/all) | Thymic histology hyperplasia/involution/normal | Anti-AChR-ab (+/−/ND) | Preoperative classification | Surgical procedures | Medical treatment | NOS score | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CSR | Improved | CSR | Improved | |||||||||||
Liu/2015/China [20] | Single-center retrospective | 2007–2011 | 5.2/3.1–7.2 | 40/NA | 27/57 | NA | 21/46 | NA | 68/35/0 | 54/21/28 | I 25/IIa 25/IIb 15/IIIa 17/IIIb 18/IV 3 MGFA | Bilateral/Right VATS | Anticholinesterase; corticosteroid; Ig | 8 |
Lin/2010/Taiwan [12] | Single-center retrospective | 1995–2004 | 3.6/1–11 | 40/5–78 | 16/42 | NA | 4/18 | NA | 42/14/4 | 39/10/11 | I 22/II 30/III 4/IV 1/V 3 MGFA | Right-VATS/TS | anticholinesterase; corticosteroid | 8 |
Zieliński/2004/Poland [21] | Single-center retrospective | 1996–1999 | NA/3.5–6.5 | 40/14–70 | 25/52 | NA | 2/6 | NA | 33/15/10 | NA | I 5/IIa 19/IIb 34 Osserman | TS | Anticholinesterase; corticosteroid; immuno-suppressant | 8 |
Mantegazza/2003/Italy [22] | Single-center prospective | NA | NA 1–6 | 40/NA | 72/185 | NA | 2/21 | NA | 130/76/0 | 169/37/0 | I 19/IIIa 63/IIIb 99/IVb 25 MGFA | Bilateral VATET/TS | Anticholinesterase; immuno-suppressant | 8 |
Mack/1996/USA [23] | Multicenter retrospective | 1992–1995 | NA/0.3–3.9 | 40/9–84 | 5/21 | 14/21 | 1/6 | 3/6 | 19/2/6 | NA | I 2/II 23/III 2 Osserman | VATS | Anticholinesterase; steroids | 7 |
Frist/1994/USA [24] | Single-center retrospective | 1971–1992 | NA/0.8–21 | 45/2–67 | 12/33 | 19/33 | 2/9 | 3/9 | NA | 20/8/14 | I 2/II 7/III 11/IV 19/V 3 Oosterhuis | TS | Anticholinesterase; corticosteroid | 7 |
Maggi/1989/Italy [25] | Single-center retrospective | 1973–1987 | NA/5–10 | 40/NA | 137/326 | 152/326 | 31/117 | 67/117 | NA | NA | I 27/IIa 256/IIb 200/III 17 own classification | TC/TC + TS | Anticholinesterase; corticosteroid; immuno- suppressant; plasmapheresis | 8 |
Monden/1985/Japan [26] | Single-center retrospective | NA | 5/NA | 50/16–59 | 21/32 | 9/32 | 2/4 | 2/4 | NA | NA | I 5/IIa 29/IIb 67/III 1 Oosterhuis | TS | NA | 8 |
Rubin/1981/USA [27] | Single-center retrospective | 1961–1982 | NA/0.5–15 | 40/9–54 | 9/18 | 9/18 | 1/3 | 2/3 | 13/3/5 | 6/15/0 | II 6/III 6/IV 8/V 1 Osserman | TS | Anticholinesterase; corticosteroid; plasmapheresis | 7 |