Fig. 3

Brain MRI at baseline and after approximately two years of treatment with cerliponase alfa. Axial T1-weighted MR images at the level of the lateral ventricles. In patient 1 cerebral atrophy with ex vacuo ventricular dilatation was already present at 42 months of age (baseline), whereas no cerebral atrophy was present in patient 2 at 48 months of age after 2 years of treatment with cerliponase alfa