Skip to main content

Table 2 Biological results

From: Long-term renal outcome in methylmalonic acidemia in adolescents and adults

  Median Min–Max Standards
Measured GFR (mL/min/1.73 m2) 56.5 23–105 > 90
Estimated GFR by Schwartz formula (mL/min/1.73 m2) 77 26–123 > 90
Estimated GFR by CKD-EPI (mL/min/1.73 m2) 112 31–144 > 90
Serum laboratory data
Urea (mmol/L) 3.8 2.4–8.1 2.5–8.0
Sodium (mmol/L) 138 135–141 136–146
Potassium (mmol/L) 3.8 2.8–4.7 3.5–4.5
Chloride (mmol/L) 105 100–108 98–107
Uric acid (µmol/L) 421 202–703 150–350
Magnesium (mmol/L) 0.83 0.68–0.96 0.85–1.15
Alkaline reserve (mmol/L) 25 22.3–30 22–29
Total calcium (mmol/L) 2.3 2.2–2.6 2.25–2.6
Ionized calcium (mmol/L) 1.17 1.13–1.24 1.15–1.34
Phosphorus (mmol/L) 1.0 0.79–1.4 0.85–1.5
PTH (pg/mL) 47.2 28.9–106.6 10–50
25OH vitamin D (ng/mL) 28 15–76 30–80
1–25 OH vitamin D (pg/mL) 43 23–106 30–60
Urinary parameters
Fractional excretion of sodium (%) 1.1 0.2–7.0 NA
Potassium (mmol/L) 47.5 13.4–118 NA
Fractional excretion of potassium (%) 20.8 5.7–63.9 NA
Calcium (mmol/L) 0.5 0.5–2.77  < 3.6
Calcium (mmol/mmol)** 0.07 0.02–0.28  < 0.55
Fractional excretion of calcium (%) 1.8 0.5–4.1 NA
Fractional excretion of urea (%) 5.1 0.04–12.2 NA
Fractional excretion of phosphate (%) 9.6 1.5–48.6 NA
Fractional excretion of magnesium (%) 4.9 2.0–11.3 NA
TmP-GFR (mmol/L)* 0.9 0.5–1.4 0.7–1.4
Proteinuria (mg/mmol)** 8.5 0–34.6  < 50
Microalbuminuria (mg/mmol)** 0.8 0–15.4  < 35
β2-microglobulinuria (µg/mmol)** 6.0 0–506  < 35
  1. GFR, glomerular filtration rate; NA, non-applicable; TmP-GFR, tubular maximum reabsorption capacity of phosphate
  2. *Urinary analytes per mmol of urinary creatinine
  3. **mGFR was used to calculate TmP-GFR