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Table 2 Biological results

From: Long-term renal outcome in methylmalonic acidemia in adolescents and adults

 

Median

Min–Max

Standards

Measured GFR (mL/min/1.73 m2)

56.5

23–105

> 90

Estimated GFR by Schwartz formula (mL/min/1.73 m2)

77

26–123

> 90

Estimated GFR by CKD-EPI (mL/min/1.73 m2)

112

31–144

> 90

Serum laboratory data

Urea (mmol/L)

3.8

2.4–8.1

2.5–8.0

Sodium (mmol/L)

138

135–141

136–146

Potassium (mmol/L)

3.8

2.8–4.7

3.5–4.5

Chloride (mmol/L)

105

100–108

98–107

Uric acid (µmol/L)

421

202–703

150–350

Magnesium (mmol/L)

0.83

0.68–0.96

0.85–1.15

Alkaline reserve (mmol/L)

25

22.3–30

22–29

Total calcium (mmol/L)

2.3

2.2–2.6

2.25–2.6

Ionized calcium (mmol/L)

1.17

1.13–1.24

1.15–1.34

Phosphorus (mmol/L)

1.0

0.79–1.4

0.85–1.5

PTH (pg/mL)

47.2

28.9–106.6

10–50

25OH vitamin D (ng/mL)

28

15–76

30–80

1–25 OH vitamin D (pg/mL)

43

23–106

30–60

Urinary parameters

Fractional excretion of sodium (%)

1.1

0.2–7.0

NA

Potassium (mmol/L)

47.5

13.4–118

NA

Fractional excretion of potassium (%)

20.8

5.7–63.9

NA

Calcium (mmol/L)

0.5

0.5–2.77

 < 3.6

Calcium (mmol/mmol)**

0.07

0.02–0.28

 < 0.55

Fractional excretion of calcium (%)

1.8

0.5–4.1

NA

Fractional excretion of urea (%)

5.1

0.04–12.2

NA

Fractional excretion of phosphate (%)

9.6

1.5–48.6

NA

Fractional excretion of magnesium (%)

4.9

2.0–11.3

NA

TmP-GFR (mmol/L)*

0.9

0.5–1.4

0.7–1.4

Proteinuria (mg/mmol)**

8.5

0–34.6

 < 50

Microalbuminuria (mg/mmol)**

0.8

0–15.4

 < 35

β2-microglobulinuria (µg/mmol)**

6.0

0–506

 < 35

  1. GFR, glomerular filtration rate; NA, non-applicable; TmP-GFR, tubular maximum reabsorption capacity of phosphate
  2. *Urinary analytes per mmol of urinary creatinine
  3. **mGFR was used to calculate TmP-GFR