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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Enzyme replacement therapy and hematopoietic stem cell transplant: a new paradigm of treatment in Wolman disease

Fig. 4

Patient 3 liver biopsies pre (a) and post (b) HCT showing improvement over time. The post HCT biopsy b shows reduced numbers of portal tract foamy macrophages, including those containing cholesterol cleft (arrowheads) and reduced portal inflammation. Early hepatocellular ballooning is seen in the pre HCT biopsy (a) but not in the post HCT biopsy (b, arrows) (both haematoxylin and eosin stained FFPE sections, × 400 original magnification)

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