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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Enzyme replacement therapy and hematopoietic stem cell transplant: a new paradigm of treatment in Wolman disease

Fig. 1

Patient 2 duodenal biopsies post HCT showing improvement overtime. a Was taken in 2017, b was taken in 2019. b shows reduced numbers of foamy macrophages in the lamina propria (arrowheads) and repopulation by lymphoplasmacytic cells (both haematoxylin and eosin stained FFPE sections, × 400 original magnification). c Is duodenal tissue from Patient 2 examined using X/Y chromosome FISH. The X probe is red and the Y probe is green. The patient was female (XX) and the HCT donor was male (XY). The native duodenal glands (G) show the presence of only red X probes but donor cells in the lamina propria show both red X and green Y probes (arrows) (insert is control male tissue showing both probes)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172