From: French recommendations for the management of systemic sclerosis
Diffuse skin damage |
Rapid progression of skin damage |
Duration of disease progression < 3–5 years |
Recent cardiac event |
 Pericarditis |
 Left ventricular failure |
Anemia of recent onset |
Anti-RNA polymerase III antibodies |
Prednisone treatment > 15 mg/day within the last 3 months |