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Table 4 Lipid profiles in the pediatric and adult groups

From: Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation

  Pediatric group (< 18 years at baseline)
N = 30 		Adult group (≥ 18 years at baseline)
N = 29
n
Mean (SD)
Baseline Year 1 Final Baseline Year 1 Final
Total cholesterol (mmol/L) 29
5.71 (1.46) 		28
5.46 (1.48) 		15
5.35 (1.15) 		29
6.08 (2.19) 		22
6.19 (2.3) 		17
5.63 (1.89)
LDL (mmol/L) 29
4.05 (1.32) 		28
3.89 (1.28) 		15
3.62 (1.14) 		28
4.27 (1.55) 		22
4.43 (2.04) 		17
4.01 (1.75)
HDL (mmol/L) 29
0.65 (0.28) 		28
0.62 (0.27) 		15
0.64 (0.28) 		29
0.69 (0.25) 		22
0.66 (0.25) 		17
0.68
(0.35)
TG
(mmol/L) 		29
2.28 (1.02) 		28
2.13 (1.04) 		15
2.39 (0.98) 		29
2.26 (1.21) 		22
2.50 (1.17) 		17
2.04 (0.99)
Cholesterol risk ratio (total cholesterol/HDL) 8.8 8.8 8.4 8.8 9.4 8.3
  1. HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglyceride
  2. Normal ranges (adults): Total cholesterol: US < 5.18 mmol/L; UK 0–3.9 mmol/L; HDL normal range: US male > 0.78; US female > 0.91 mmol/L; UK > 1.2 mmol/L; LDL normal range: US < 3.34 mmol/L; UK 0–2 mmol/L; triglycerides normal range: < 1.7 mmol/L
  3. Normal ranges (child and adolescent): total cholesterol: not available; HDL normal range: 0.78–1.94 mmol/L; LDL normal range: 1.69–3.63 mmol/L; triglycerides normal range: 0.34–1.67 mmol/L
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172