Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation

Table 4 Lipid profiles in the pediatric and adult groups

	Pediatric group (< 18 years at baseline) N = 30			Adult group (≥ 18 years at baseline) N = 29
	n Mean (SD)
	Baseline	Year 1	Final	Baseline	Year 1	Final
Total cholesterol (mmol/L)	29 5.71 (1.46)	28 5.46 (1.48)	15 5.35 (1.15)	29 6.08 (2.19)	22 6.19 (2.3)	17 5.63 (1.89)
LDL (mmol/L)	29 4.05 (1.32)	28 3.89 (1.28)	15 3.62 (1.14)	28 4.27 (1.55)	22 4.43 (2.04)	17 4.01 (1.75)
HDL (mmol/L)	29 0.65 (0.28)	28 0.62 (0.27)	15 0.64 (0.28)	29 0.69 (0.25)	22 0.66 (0.25)	17 0.68 (0.35)
TG (mmol/L)	29 2.28 (1.02)	28 2.13 (1.04)	15 2.39 (0.98)	29 2.26 (1.21)	22 2.50 (1.17)	17 2.04 (0.99)
Cholesterol risk ratio (total cholesterol/HDL)	8.8	8.8	8.4	8.8	9.4	8.3

HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglyceride
Normal ranges (adults): Total cholesterol: US < 5.18 mmol/L; UK 0–3.9 mmol/L; HDL normal range: US male > 0.78; US female > 0.91 mmol/L; UK > 1.2 mmol/L; LDL normal range: US < 3.34 mmol/L; UK 0–2 mmol/L; triglycerides normal range: < 1.7 mmol/L
Normal ranges (child and adolescent): total cholesterol: not available; HDL normal range: 0.78–1.94 mmol/L; LDL normal range: 1.69–3.63 mmol/L; triglycerides normal range: 0.34–1.67 mmol/L

ISSN: 1750-1172