Table 1 Population characteristics and disease history
| Parameter |
Pediatric cohort (age < 18 at baseline) N = 30 |
Adult cohort (age ≥ 18 at baseline) N = 29 | ||||
|---|---|---|---|---|---|---|
| Age range at baseline year | 7–17 | 18–64 | ||||
| Age distribution n (years) |
BL N = 30 |
Yr1 N = 28 |
Final N = 15 |
BL N = 29 |
Yr1 N = 22 |
Final N = 17 |
| 6–11 | 12 | 7 | 0 | 0 | 0 | 0 |
| 12–17 | 18 | 19 | 1 | 0 | 0 | 0 |
| 18–23 | 0 | 2 | 10 | 10 | 9 | 2 |
| 24–30 | 0 | 0 | 4 | 3 | 2 | 2 |
| 31–40 | 0 | 0 | 0 | 9 | 7 | 4 |
| 41–50 | 0 | 0 | 0 | 5 | 3 | 7 |
| > 50 | 0 | 0 | 0 | 2 | 1 | 2 |
| Sex, n (%) | ||||||
| Male | 20 (66.7) | 11 (37.9) | ||||
| Female | 10 (33.3) | 18 (62.1) | ||||
| Ethnicity, n (%) | ||||||
| Caucasian | 27 (90.0) | 27 (93.1) | ||||
| Black | 0 | 1 (3.4) | ||||
| Hispanic | 0 | 0 | ||||
| Asian | 0 | 0 | ||||
| Other | 3 (10.0) | 1 (3.4) | ||||
| Age at symptom onset | ||||||
| Mean (SD), years | 2.52 (2.8) | 7.94 (8.8) | ||||
| Median (range) | 2.00 (0.1,14.0) | 4.00 (0.9, 30) | ||||
| Age at diagnosis | ||||||
| Mean (SD), years | 5.23 (3.6) | 15.10 (13.5) | ||||
| Median (range) | 3.63 (1, 14.3) | 11.00 (2, 45.1) | ||||
| Splenectomy n (%) | ||||||
| Partial | 0 | 1 ( 3.4) | ||||
| Total | 0 | 4 ( 13.8) | ||||