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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation

Fig. 5

Hepatomegaly during the observation period. Liver volumes in multiples of normal (MN) in the pediatric (a) and adult (b) cohorts at baseline (BL), year 1, and final assessment. Severity of hepatomegaly cutoffs are indicated by solid lines where mild is < 1.25 MN, moderate is ≥ 1.25 and ≤ 2.5 MN, and severe is > 2.5 MN [15]

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