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Table 3 Direct costs for the 3-month study period for the total patient group (n = 192; in 2019 Euro)

From: Direct and indirect costs and cost-driving factors in adults with tuberous sclerosis complex: a multicenter cohort study and a review of the literature

Cost components

Mean costs

SD1

Minimum

Median

Maximum

95% CI

% of total direct costs

Estimated annual direct costs2

Total direct costs

6452

7584

0

1920

29,182

5533; 7422

100

25,808

 Medication (n = 165)

4953

6854

0

573

28,224

4087; 5876

76.8

19,812

  mTOR inhibitors* (n = 71)

4358

6520

0

0

25,273

3448; 5342

67.5

17,432

  Antiseizure drugs (ASDs) (n = 123)

415

1962

0

104

26,538

239; 706

6.4

1660

  Other prescription drugs (n = 104)

132

385

0

8

2606

84; 186

2.0

528

  OTC drugs and supplements (n = 70)

41

100

0

0

700

29; 54

0.6

164

  Emergency medication/medication on demand (n = 42)

7

36

0

0

347

3; 13

0.1

28

 Hospitalization (n = 23)

518

1691

0

0

11,487

312; 750

8.0

2072

 Outpatient treatment (n = 157)

467

1156

0

194

15,097

352; 626

7.2

1868

 Diagnostics (n = 140)

155

242

0

44

1691

124; 192

2.4

620

 Ancillary therapies (n = 54)

125

307

0

0

2120

84; 174

1.9

500

 Auxillary material (n = 14)

49

253

0

0

2235

18; 87

0.8

196

 Rehabilitation (n = 2)

40

410

0

0

4983

0; 92

0.6

160

 Emergency service use (n = 9)

44

217

0

0

1800

19; 75

0.7

176

 Specific diets (n = 3)

9

97

0

0

1200

0; 23

0.1

36

 Transport costs (n = 25)

5

17

0

0

130

3; 7

0.1

20

 Co-payments for therapies (n = 17)

39

177

0

0

1400

19; 64

0.6

156

 Other co-payments (n = 45)

48

183

0

0

1700

27; 75

0.7

192

  1. 95% CI = 95% Confidence interval using the bootstrap bias corrected and accelerated method
  2. 1Standard deviation, 2Estimation based on the mean costs in three months multiplied by four
  3. *Everolimus n = 69, Sirolimus n = 2, OTC = over-the-counter