Fig. 4
A male subject with hypohidrotic Ectodermal Dysplasia (HED) and EDA1 gene variant, demonstrating bilateral acquired ptosis and lash ptosis. Note the typical ED presentation with light and sparse eyelashes and eyebrow hair (hypotrichosis), and progressive periocular skin changes. a The patient at age 5 months, with normal eyelid position. b Age 10, demonstrating mild bilateral ptosis, lash ptosis, and periocular skin changes. c Age 14, with progression of his bilateral ptosis, lash ptosis, and periocular pigmentary skin changes